Marosi C, Bettelheim P, Chott A, Köller U, Kreiner G, Steger G, Jäger U, Pirc-Danoewinata H, Lechner K
First Department of Medicine, University of Vienna, Austria.
Ann Hematol. 1992 Feb;64(2):101-4. doi: 10.1007/BF01715354.
A young male patient progressed rapidly from localized abdominal lymph node enlargement to overt acute lymphoblastic leukemia. Despite aggressive treatment, he died of progressive CNS leukemia 5 months after initial presentation. At diagnosis, karyotypic analysis of an abdominal lymph node revealed the coexistence of t(14;18) (q32;q21), specific for follicular lymphoma, and t(8;22) (q24;q11), a variant Burkitt translocation. Such cases might be considered as a model for a general mechanism of tumor progression with cascade-like involvement of oncogenes.
一名年轻男性患者从局限性腹部淋巴结肿大迅速发展为明显的急性淋巴细胞白血病。尽管进行了积极治疗，但他在初次就诊后5个月死于进行性中枢神经系统白血病。诊断时，对腹部淋巴结进行的核型分析显示存在t(14;18)(q32;q21)，这是滤泡性淋巴瘤的特异性标记，以及t(8;22)(q24;q11)，一种变异型伯基特易位。此类病例可被视为癌基因呈级联式累及的肿瘤进展一般机制的模型。
