Roingeard P, Sankalé J L, Dubois F, Diouf A, Bacha A, Mboup S, Goudeau A
Département de Microbiologie Médicale et Moléculaire, Unité de Virologie URA CNRS 1334, Hôpital Bretonneau, Tours, France.
Clin Infect Dis. 1992 Feb;14(2):510-4. doi: 10.1093/clinids/14.2.510.
A review of the literature shows strong variations in the prevalence of hepatitis delta virus (HDV) among Africans seropositive for hepatitis B surface antigen (HBsAg). In Senegal, West Africa, prevalence of antibodies to HDV among asymptomatic HBsAg carriers appears to be linked to regional and/or socioeconomic factors. Antibodies to HDV were found in 22 (47%) of 47 HBsAg-seropositive patients with liver disease who were hospitalized in the main hospital of Dakar and in 4% to 44% of asymptomatic HBsAg carriers. Eight (36%) of 22 patients with liver disease were seropositive for IgM antibodies to HDV, whereas none of 18 asymptomatic subjects were seropositive (P less than .01). According to studies conducted in Europe and the United States, the presence of this marker may constitute support for the argument that HDV plays a role in the development of HBsAg-associated liver diseases in Senegal and, presumably, within the African continent.
文献综述显示，在乙型肝炎表面抗原（HBsAg）血清学阳性的非洲人中，丁型肝炎病毒（HDV）的流行率存在很大差异。在西非的塞内加尔，无症状HBsAg携带者中HDV抗体的流行率似乎与区域和/或社会经济因素有关。在达喀尔主要医院住院的47例患有肝病的HBsAg血清学阳性患者中，有22例（47%）检测到HDV抗体，无症状HBsAg携带者中的HDV抗体检测率为4%至44%。22例肝病患者中有8例（36%）HDV IgM抗体血清学阳性，而18例无症状受试者中无一例血清学阳性（P<0.01）。根据在欧洲和美国进行的研究，这一标志物的存在可能支持以下观点，即HDV在塞内加尔以及大概在非洲大陆的HBsAg相关肝病发展中起作用。
