Kubík A K, Zatloukal P, Tomásek L, Pauk N, Havel L, Krepela E, Petruzelka L
Department of Pneumology and Thoracic Surgery, Charles University, 3rd Faculty of Medicine, University Hospital Na Bulovce, and Postgraduate Medical Institute, Budinova 2, CZ-18081 Prague, Czech Republic.
Eur J Cancer Prev. 2004 Dec;13(6):471-80. doi: 10.1097/00008469-200412000-00002.
A case-control study was conducted to investigate the relationship between diet and the risk of lung cancer among women non-smokers and to compare with women smokers in the same population. Data collected by personal interviews from 435 microscopically confirmed cases and 1710 controls were analysed using unconditional logistic regression. In addition to results for all study subjects, associations between diet and lung cancer risk were compared between two highly contrasting groups: smokers (odds ratio (OR) 7.03) and non-smokers (OR 1.00). A protective effect of frequent (daily or several times per week) black tea drinking appeared among non-smoking women (OR 0.65, 95% confidence interval (CI) 0.43-0.99). Among smoking women, protective effects were observed for frequent intake of milk/dairy products (OR 0.56, 95% CI 0.32-0.96), coffee (OR 0.47, 95% CI 0.25-0.88), and wine consumption (daily or weekly OR 0.60, 95% CI 0.37-0.98; monthly OR 0.60, 95% CI 0.39-0.94). Inverse associations with the risk appeared for physical exercise for smokers only, and for the body mass index both among non-smoking and smoking women. Some items of diet may contribute to variation in risk among women in the Czech Republic; their importance seems to vary in relation to their status in smoking, the dominant factor in the aetiology of lung cancer.
开展了一项病例对照研究,以调查不吸烟女性的饮食与肺癌风险之间的关系,并与同一人群中的吸烟女性进行比较。通过个人访谈收集了435例经显微镜确诊的病例和1710名对照的数据,采用非条件逻辑回归进行分析。除了所有研究对象的结果外,还比较了两个形成强烈对比的组之间饮食与肺癌风险的关联:吸烟者(优势比(OR)7.03)和不吸烟者(OR 1.00)。经常(每天或每周几次)饮用红茶对不吸烟女性有保护作用(OR 0.65,95%置信区间(CI)0.43 - 0.99)。在吸烟女性中,经常摄入牛奶/乳制品(OR 0.56,95% CI 0.32 - 0.96)、咖啡(OR 0.47,95% CI 0.25 - 0.88)和饮酒(每天或每周OR 0.60,95% CI 0.37 - 0.98;每月OR 0.60,95% CI 0.39 - 0.94)有保护作用。仅在吸烟者中,体育锻炼与风险呈负相关,在不吸烟和吸烟女性中,体重指数与风险均呈负相关。在捷克共和国,某些饮食项目可能导致女性患癌风险存在差异;其重要性似乎因吸烟状况而异,吸烟是肺癌病因中的主要因素。