Sawyers Charles
Howard Hughes Medical Institute, David Geffen School of Medicine at UCLA, Jonsson Comprehensive Cancer Center, 10833 LeConte Avenue, Los Angeles, California 90095, USA.
Nature. 2004 Nov 18;432(7015):294-7. doi: 10.1038/nature03095.
Disruption of the normal regulation of cell-cycle progression and division lies at the heart of the events leading to cancer. Complex networks of regulatory factors, the tumour microenvironment and stress signals, such as those resulting from damaged DNA, dictate whether cancer cells proliferate or die. Recent progress in understanding the molecular changes that underlie cancer development offer the prospect of specifically targeting malfunctioning molecules and pathways to achieve more effective and rational cancer therapy.
细胞周期进程和分裂的正常调控被破坏是导致癌症的核心事件。复杂的调控因子网络、肿瘤微环境和应激信号，比如由受损DNA产生的信号，决定了癌细胞是增殖还是死亡。在理解癌症发展背后的分子变化方面的最新进展为特异性靶向功能失调的分子和通路以实现更有效、更合理的癌症治疗带来了希望。
