Kastan Michael B, Bartek Jiri
Department of Hematology-Oncology, St Jude Children's Research Hospital, 332 North Lauderdale Street, Memphis, Tennessee 38105, USA.
Nature. 2004 Nov 18;432(7015):316-23. doi: 10.1038/nature03097.
All life on earth must cope with constant exposure to DNA-damaging agents such as the Sun's radiation. Highly conserved DNA-repair and cell-cycle checkpoint pathways allow cells to deal with both endogenous and exogenous sources of DNA damage. How much an individual is exposed to these agents and how their cells respond to DNA damage are critical determinants of whether that individual will develop cancer. These cellular responses are also important for determining toxicities and responses to current cancer therapies, most of which target the DNA.
地球上的所有生命都必须应对持续暴露于诸如太阳辐射等DNA损伤剂的情况。高度保守的DNA修复和细胞周期检查点通路使细胞能够应对内源性和外源性DNA损伤源。个体接触这些因素的程度以及其细胞对DNA损伤的反应，是该个体是否会患癌症的关键决定因素。这些细胞反应对于确定毒性以及对当前大多数针对DNA的癌症治疗的反应也很重要。
