Chen Tun-Chieh, Perng Daw-Shyong, Tsai Jih-Jin, Lu Po-Liang, Chen Tyen-Po
Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung 807, Taiwan.
J Formos Med Assoc. 2004 Nov;103(11):865-8.
Dengue fever is an acute febrile viral disease, which frequently presents with high fever, headache, bone pain and skin rash. Acute pancreatitis and seizure are rare manifestations of dengue virus infection. A 66-year-old woman with diabetes mellitus presented with epigastralgia, nausea, vomiting, diarrhea and fever. Acute pancreatitis, abnormal liver function and thrombocytopenia were diagnosed at a local hospital. After persistent fever, thrombocytopenia and seizure developed she was transferred to our medical center. Dengue virus infection was confirmed by serology study and dengue hemorrhagic fever grade II was diagnosed. No further neurological symptoms occurred and pancreatitis improved gradually after supportive care. She recovered and had no sequelae at 1 year follow-up. Acute pancreatitis and seizure may be manifestations of dengue virus infection, especially in patients with delayed diagnosis, prolonged fever and thrombocytopenia.
登革热是一种急性发热性病毒性疾病，常表现为高热、头痛、骨痛和皮疹。急性胰腺炎和癫痫发作是登革病毒感染的罕见表现。一名66岁的糖尿病女性患者出现上腹痛、恶心、呕吐、腹泻和发热。当地医院诊断为急性胰腺炎、肝功能异常和血小板减少。持续发热、血小板减少和癫痫发作后，她被转至我们的医疗中心。血清学研究证实为登革病毒感染，诊断为II级登革出血热。经支持治疗后，未再出现神经系统症状，胰腺炎逐渐好转。随访1年时她康复且无后遗症。急性胰腺炎和癫痫发作可能是登革病毒感染的表现，尤其是在诊断延迟、发热持续时间长和血小板减少的患者中。
