D'Andrea G, Perini F, Terrazzino S, Nordera G P
Headache and Cerebrovascular Diseases Center, Villa Margherita Neurological Clinic, Arcugnano (VI), Italy.
Neurol Sci. 2004 Oct;25 Suppl 3:S89-92. doi: 10.1007/s10072-004-0260-1.
We briefly summarise biochemical anomalies of serotonin, norepinephrine, glutamic and aspartic acids, the main neurotransmitters of inhibitory and excitatory neuronal circuitries, found in primary headaches and their relationship with pathogenesis of migraine and cluster headache (CH). In addition, the high levels of circulating tyramine, octopamine and synephrine (elusive amines), recently reported in both migraine types and CH, are discussed in relation to the other "classic" amines findings. In particular it is suggested how abnormal levels of elusive amines may participate in the pathophysiology of migraine and CH acting through their specific trace amine receptors and alpha and beta receptors. The possible hypothesis that emerges from the analysis of these biochemical findings is that an imbalance of systems, with opposite neurophysiological functions related to the pain and other yet unknown functions, may constitute the biochemical phenotype of migraine with and without aura, and CH.
我们简要总结了血清素、去甲肾上腺素、谷氨酸和天冬氨酸（抑制性和兴奋性神经回路的主要神经递质）的生化异常情况，这些异常在原发性头痛中被发现，以及它们与偏头痛和丛集性头痛（CH）发病机制的关系。此外，最近在偏头痛和丛集性头痛中均有报道的循环酪胺、章胺和辛弗林（难以捉摸的胺类）的高水平，也结合其他“经典”胺类的研究结果进行了讨论。特别是，有人提出难以捉摸的胺类的异常水平可能通过其特定的痕量胺受体以及α和β受体参与偏头痛和丛集性头痛的病理生理过程。从这些生化研究结果分析中得出的可能假设是，具有与疼痛及其他未知功能相关的相反神经生理功能的系统失衡，可能构成有先兆和无先兆偏头痛以及丛集性头痛的生化表型。
