Ostuzzi Roberto, D'Andrea Giovanni, Francesconi Federica, Musco Francesca
ED Center of Eating Disorders, Villa Margherita Neurology Clinic, Via Costacolonna 20, 36057 Arcugnano, Italy.
Neurol Sci. 2008 May;29 Suppl 1:S83-7. doi: 10.1007/s10072-008-0894-5.
The eating disorders (ED) anorexia nervosa (AN) and bulimia nervosa (BN) are important psychiatric and somatic conditions occurring mainly in young women. The aetiology is unknown, but there are social, biological and psychological factors that play a relevant role in the pathogenesis, along with multiple endocrine abnormalities. Hypothalamic monoamines (especially serotonin), neuropeptides (especially neuropeptide Y and cholecystokinin) and leptin are involved in the regulation of the human appetite. ED share with migraine the same metabolic profile and aspect of psychiatric and psychological conditions. In support of this hypothesis in one study, it has been shown that the incidence of migraine is high in these patients; and it has been shown that the incidence in a female group that suffers from migraine was greater than in the normal population. In order to understand the possible relationship between migraine and ED, we have investigated the incidence of primary headache in a group of AN and BN patients. The result of this study shows that the prevalence of migraine in women affected by AN and BN is very high (75%) in comparison to the general population (12.5% headache incidence in normal population). In most patients the onset of migraine attacks began before or at the same time as the symptoms of AN and BN. We suggest that migraine is a predisposing condition for the occurence of AD in young women.
饮食失调（ED）中的神经性厌食症（AN）和神经性贪食症（BN）是主要发生在年轻女性中的重要精神和躯体疾病。其病因尚不清楚，但社会、生物和心理因素在发病机制中起相关作用，同时还伴有多种内分泌异常。下丘脑单胺（尤其是血清素）、神经肽（尤其是神经肽Y和胆囊收缩素）和瘦素参与人体食欲的调节。饮食失调与偏头痛在代谢特征以及精神和心理状况方面具有相同之处。在一项研究中，为支持这一假设，已表明这些患者中偏头痛的发病率很高；并且已表明患有偏头痛的女性组的发病率高于正常人群。为了了解偏头痛与饮食失调之间的可能关系，我们调查了一组神经性厌食症和神经性贪食症患者中原发性头痛的发病率。这项研究的结果表明，与普通人群相比（正常人群头痛发病率为12.5%），患有神经性厌食症和神经性贪食症的女性中偏头痛的患病率非常高（75%）。在大多数患者中，偏头痛发作的开始时间早于或与神经性厌食症和神经性贪食症的症状同时出现。我们认为偏头痛是年轻女性发生饮食失调的一个诱发因素。
