Wang Peng, Qin Hai-Lin, Zhang Ling, Li Zhi-Hong, Wang Ying-Hong, Zhu Hai-Bo
Institute of Materia Medica, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing , P.R. China.
Planta Med. 2004 Nov;70(11):1075-9. doi: 10.1055/s-2004-832650.
A chemical investigation of the roots of Cynanchum stauntonii has resulted in the characterization of a new hydroperoxide with a 13,14 : 14,15-disecopregnane-type skeleton, named stauntonine (1), together with three related compounds, anhydrohirundigenin (2), anhydrohirundigenin monothevetoside (3), and glaucogenin-C mono- D-thevetoside (4). Their structures were established by spectroscopic methods, including X-ray crystallographic diffraction analysis of stauntonine that confirmed its relative stereochemistry. The compound 1 showed dose-dependent relaxation on aortic rings with endothelium contracted by phenylepherine or KCl.
对柳叶白前根部进行的化学研究，已鉴定出一种具有13,14:14,15-断孕甾烷型骨架的新型氢过氧化物，命名为白前素（1），同时还鉴定出三种相关化合物，脱水马利筋苷元（2）、脱水马利筋苷元单黄花夹竹桃苷（3）和青阳参苷元-C单-D-黄花夹竹桃苷（4）。通过光谱方法确定了它们的结构，包括对白前素进行X射线晶体衍射分析，证实了其相对立体化学结构。化合物1对苯肾上腺素或氯化钾收缩的内皮完整主动脉环呈现剂量依赖性舒张作用。
