来自白薇根的具有5α:9α-过氧和Δ-二烯键的14,15-断孕甾烷型糖苷。
14,15-Secopregnane-Type Glycosides with 5α:9α-Peroxy and Δ-diene Linkages from the Roots of Cynanchum stauntonii.
作者信息
Deng An-Jun, Yu Jin-Qian, Li Zhi-Hong, Ma Lin, Zhang Zhi-Hui, Qin Hai-Lin
机构信息
State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China.
Shandong Analysis and Test Center, Shandong Academy of Sciences, Jinan 250014, Shandong, China.
出版信息
Molecules. 2017 May 23;22(6):860. doi: 10.3390/molecules22060860.
Three new 14,15-secopregnane-type glycosides, stauntosides UA, UA₁, and UA₂, were isolated from the roots of . The three compounds share the first reported and same basic structural features of 3β-hydroxy-14:16,15:20,18:20-triepoxy-5α:9α-peroxy-14,15-secopregnane-6,8(14)-diene named as stauntogenin G as the aglycones. The structures of the new compounds were characterized on the basis of extensive spectroscopic analyses, mainly 1D and 2D NMR and MS methods and chemical analysis. The isolation and identification of the new compounds graced the structural diversity of pregnane-type steroids from .
从……的根部分离出了三种新的14,15-断孕甾烷型糖苷，即斯陶托苷UA、UA₁和UA₂。这三种化合物具有首次报道的相同基本结构特征，以3β-羟基-14:16、15:20、18:20-三环氧-5α:9α-过氧-14,15-断孕甾烷-6,8(14)-二烯（命名为斯陶托配基G）作为苷元。新化合物的结构通过广泛的光谱分析进行表征，主要采用一维和二维核磁共振以及质谱方法和化学分析。新化合物的分离和鉴定丰富了来自……的孕甾烷型甾体的结构多样性。
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