来自真菌肾形葡萄穗霉的具有抗病毒和抗疟活性的螺二氢苯并呋喃萜类化合物。

Antiviral and antiplasmodial spirodihydrobenzofuran terpenes from the fungus Stachybotrys nephrospora.

作者信息

Sawadjoon Supaporn, Kittakoop Prasat, Isaka Masahiko, Kirtikara Kanyawim, Madla Siribhorn, Thebtaranonth Yodhathai

机构信息

Department of Chemistry, Faculty of Science, Mahidol University, Bangkok, Thailand.

出版信息

Planta Med. 2004 Nov;70(11):1085-7. doi: 10.1055/s-2004-832652.

DOI:10.1055/s-2004-832652

PMID:15549667

Abstract

Two known spirodihydrobenzofuran terpenes (1 and 2) were isolated from a mycelium extract of the fungus Stachybotrys nephrospora BCC 3900. Compound 1 (Mer-NF5003F or stachybotrydial) exhibited potent antiviral activity (the IC50 value of 4.32 microg/mL) comparable to the standard drug, acyclovir, while compound 2 was inactive against the HSV-1 virus. Both 1 and 2 possessed antiplasmodial activity (IC50 values of 0.85 and 0.15 microg/mL for 1 and 2, respectively), and were not toxic towards the Vero cell line. A regiospecific conversion of the dialdehyde 1 to the lactone 2 proceeded simply under acidic conditions.

摘要

从真菌链格孢菌BCC 3900的菌丝体提取物中分离出两种已知的螺二氢苯并呋喃萜类化合物（1和2）。化合物1（Mer-NF5003F或链格孢醛）表现出强效的抗病毒活性（IC50值为4.32微克/毫升），与标准药物阿昔洛韦相当，而化合物2对单纯疱疹病毒1型无活性。化合物1和2均具有抗疟活性（化合物1和2的IC50值分别为0.85和0.15微克/毫升），且对Vero细胞系无毒。在酸性条件下，二醛1可简单地区域特异性转化为内酯2。