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天然存在的萜类化合物:一类有望应对流感大流行的有机分子。

Naturally Occurring Terpenes: A Promising Class of Organic Molecules to Address Influenza Pandemics.

作者信息

Al-Salihi Suhad A A, Alberti Fabrizio

机构信息

Applied Sciences Department, University of Technology, Baghdad, Iraq.

School of Life Sciences and Department of Chemistry, University of Warwick, Gibbet Hill Road, Coventry, CV4 7AL, UK.

出版信息

Nat Prod Bioprospect. 2021 Aug;11(4):405-419. doi: 10.1007/s13659-021-00306-z. Epub 2021 May 3.

Abstract

Since the olden times, infectious diseases have largely affected human existence. The newly emerged infections are excessively caused by viruses that are largely associated with mammal reservoirs. The casualties of these emergencies are significantly influenced by the way human beings interact with the reservoirs, especially the animal ones. In our review we will consider the evolutionary and the ecological scales of such infections and their consequences on the public health, with a focus on the pathogenic influenza A virus. The nutraceutical properties of fungal and plant terpene-like molecules will be linked to their ability to lessen the symptoms of viral infections and shed light on their potential use in the development of new drugs. New challenging methods in antiviral discovery will also be discussed in this review. The authors believe that pharmacognosy is the "wave of future pharmaceuticals", as it can be continually produced and scaled up under eco-friendly requirements. Further diagnostic methods and strategies however are required to standardise those naturally occurring resources.

摘要

自古以来,传染病在很大程度上影响着人类的生存。新出现的感染大多是由与哺乳动物宿主密切相关的病毒引起的。这些突发事件造成的伤亡受到人类与宿主,尤其是动物宿主相互作用方式的显著影响。在我们的综述中,我们将考虑此类感染的进化和生态尺度及其对公共卫生的影响,重点关注甲型流感病毒。真菌和植物类萜分子的营养保健特性将与其减轻病毒感染症状的能力相关联,并阐明它们在新药开发中的潜在用途。本综述还将讨论抗病毒发现中的新挑战方法。作者认为,天然药物化学是“未来药物的潮流”,因为它可以在环保要求下持续生产和扩大规模。然而,需要进一步的诊断方法和策略来规范那些天然存在的资源。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/858e/8275753/3687ae786cb7/13659_2021_306_Fig1_HTML.jpg

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