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Chlamydial Hsp60-2 is iron responsive in Chlamydia trachomatis serovar E-infected human endometrial epithelial cells in vitro.衣原体热休克蛋白60-2在体外沙眼衣原体血清型E感染的人子宫内膜上皮细胞中对铁有反应。
Infect Immun. 2007 May;75(5):2374-80. doi: 10.1128/IAI.01465-06. Epub 2007 Feb 16.
2
Ultrastructural analysis of chlamydial antigen-containing vesicles everting from the Chlamydia trachomatis inclusion.对从沙眼衣原体包涵体中翻出的含衣原体抗原小泡的超微结构分析。
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[Evidence of antibodies against the chlamydial heat shock protein (cHSP60) in women from "in vitro" fertilization program].["体外受精项目中女性体内抗衣原体热休克蛋白（cHSP60）抗体的证据"]
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Identification of iron-responsive proteins expressed by Chlamydia trachomatis reticulate bodies during intracellular growth.沙眼衣原体网状体在细胞内生长期间表达的铁反应蛋白的鉴定。
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Cervical epithelial cells from Chlamydia trachomatis-infected sites coexpress higher levels of chlamydial heat shock proteins 60 and 10 in infertile women than in fertile women.沙眼衣原体感染部位的宫颈上皮细胞在不孕妇女中的表达水平高于在生育妇女中的表达水平。
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Localization of Chlamydia trachomatis heat shock proteins 60 and 70 during infection of a human endometrial epithelial cell line in vitro.沙眼衣原体热休克蛋白60和70在体外感染人子宫内膜上皮细胞系过程中的定位
Infect Immun. 1998 May;66(5):2323-9. doi: 10.1128/IAI.66.5.2323-2329.1998.
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Frequency and magnitude of Chlamydia trachomatis elementary body- and heat shock protein 60-stimulated interferon gamma responses in peripheral blood mononuclear cells and endometrial biopsy samples from women with high exposure to infection.衣原体沙眼衣原体原体和热休克蛋白60刺激的外周血单核细胞及来自高感染暴露女性子宫内膜活检样本中γ干扰素反应的频率和强度
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Antibody response to the 60-kDa chlamydial heat-shock protein is associated with scarring trachoma.对60 kDa衣原体热休克蛋白的抗体反应与瘢痕性沙眼有关。
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Antibody response to the chlamydial heat-shock protein 60 in an experimental model of chronic pelvic inflammatory disease in monkeys (Macaca nemestrina).在猕猴（食蟹猴）慢性盆腔炎实验模型中对衣原体热休克蛋白60的抗体反应。
J Infect Dis. 1999 Sep;180(3):774-9. doi: 10.1086/314919.
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[Chlamydial and human heat shock protein 60 homologues in acute coronary syndromes. (Auto-)immune reactions as a link between infection and atherosclerosis].[急性冠状动脉综合征中的衣原体和人类热休克蛋白60同源物。（自身）免疫反应作为感染与动脉粥样硬化之间的联系]
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Haptoglobin and sickle cell polymorphisms and risk of active trachoma in Gambian children.结合珠蛋白和镰状细胞多态性与冈比亚儿童活动性沙眼风险的关系。
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本文引用的文献

1
Transcriptional response patterns of Chlamydophila psittaci in different in vitro models of persistent infection.鹦鹉热衣原体在不同持续性感染体外模型中的转录反应模式。
Infect Immun. 2006 Aug;74(8):4801-8. doi: 10.1128/IAI.01487-05.
2
Chlamydia heat shock protein 60 induces trophoblast apoptosis through TLR4.沙眼衣原体热休克蛋白60通过Toll样受体4诱导滋养层细胞凋亡。
J Immunol. 2006 Jul 15;177(2):1257-63. doi: 10.4049/jimmunol.177.2.1257.
3
Protein expression profiles of Chlamydia pneumoniae in models of persistence versus those of heat shock stress response.肺炎衣原体在持续感染模型与热休克应激反应模型中的蛋白质表达谱。
Infect Immun. 2006 Jul;74(7):3853-63. doi: 10.1128/IAI.02104-05.
4
Ultrastructural analysis of chlamydial antigen-containing vesicles everting from the Chlamydia trachomatis inclusion.对从沙眼衣原体包涵体中翻出的含衣原体抗原小泡的超微结构分析。
Microbes Infect. 2006 May;8(6):1579-91. doi: 10.1016/j.micinf.2006.01.018. Epub 2006 Apr 18.
5
Chlamydia trachomatis and chlamydial heat shock protein 60-specific antibody and cell-mediated responses predict tubal factor infertility.沙眼衣原体及沙眼衣原体热休克蛋白60特异性抗体和细胞介导反应可预测输卵管因素不孕症。
Hum Reprod. 2006 Jun;21(6):1533-8. doi: 10.1093/humrep/del014. Epub 2006 Feb 14.
6
Exposure to mycobacteria primes the immune system for evolutionarily diverse heat shock proteins.接触分枝杆菌会使免疫系统对进化上不同的热休克蛋白产生预适应。
Infect Immun. 2005 Nov;73(11):7687-96. doi: 10.1128/IAI.73.11.7687-7696.2005.
7
Chlamydial GroEL autoregulates its own expression through direct interactions with the HrcA repressor protein.衣原体GroEL通过与HrcA阻遏蛋白的直接相互作用来自动调节其自身的表达。
J Bacteriol. 2005 Nov;187(21):7535-42. doi: 10.1128/JB.187.21.7535-7542.2005.
8
Regulation by iron: RNA rules the rust.铁的调控：RNA掌控铁锈。
J Bacteriol. 2005 Oct;187(20):6870-3. doi: 10.1128/JB.187.20.6870-6873.2005.
9
Immunoepidemiologic profile of Chlamydia trachomatis infection: importance of heat-shock protein 60 and interferon- gamma.沙眼衣原体感染的免疫流行病学概况：热休克蛋白60和干扰素-γ的重要性
J Infect Dis. 2005 Aug 15;192(4):591-9. doi: 10.1086/432070. Epub 2005 Jul 7.
10
Inhibition of proteolytic activity of a chlamydial proteasome/protease-like activity factor by antibodies from humans infected with Chlamydia trachomatis.沙眼衣原体感染人类产生的抗体对衣原体蛋白酶体/蛋白酶样活性因子蛋白水解活性的抑制作用
Infect Immun. 2005 Jul;73(7):4414-9. doi: 10.1128/IAI.73.7.4414-4419.2005.

衣原体热休克蛋白60-2在体外沙眼衣原体血清型E感染的人子宫内膜上皮细胞中对铁有反应。

Chlamydial Hsp60-2 is iron responsive in Chlamydia trachomatis serovar E-infected human endometrial epithelial cells in vitro.

作者信息

LaRue Richard W, Dill Brian D, Giles David K, Whittimore Judy D, Raulston Jane E

机构信息

Department of Microbiology, James H. Quillen College of Medicine, East Tennessee State University, P.O. Box 70579, Johnson City, TN 37614-1708, USA.

出版信息

Infect Immun. 2007 May;75(5):2374-80. doi: 10.1128/IAI.01465-06. Epub 2007 Feb 16.

DOI:10.1128/IAI.01465-06
PMID:17307941
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1865735/
Abstract

Chlamydial 60-kDa heat shock proteins (cHsp60s) are known to play a prominent role in the immunopathogenesis of disease. It is also known that several stress-inducing growth conditions, such as heat, iron deprivation, or exposure to gamma interferon, result in the development of persistent chlamydial forms that often exhibit enhanced expression of cHsp60. We have shown previously that the expression of cHsp60 is greatly enhanced in Chlamydia trachomatis serovar E propagated in an iron-deficient medium. The objective of this work was to determine which single cHsp60 or combination of the three cHsp60 homologs encoded by this organism responds to iron limitation. Using monospecific polyclonal peptide antisera that recognize only cHsp60-1, cHsp60-2, or cHsp60-3, we found that expression of cHsp60-2 is responsive to iron deprivation. Overall, our studies suggest that the expression of cHsp60 homologs differs among the mechanisms currently known to induce persistence.

摘要

衣原体60 kDa热休克蛋白（cHsp60s）在疾病的免疫发病机制中发挥着重要作用。已知几种应激诱导生长条件，如热、铁缺乏或暴露于γ干扰素，会导致持续性衣原体形态的形成，这些形态通常表现出cHsp60表达增强。我们之前已经表明，在缺铁培养基中繁殖的沙眼衣原体血清型E中，cHsp60的表达大大增强。这项工作的目的是确定该生物体编码的单个cHsp60或三种cHsp60同源物的组合中，哪一个对铁限制有反应。使用仅识别cHsp60-1、cHsp60-2或cHsp60-3的单特异性多克隆肽抗血清，我们发现cHsp60-2的表达对铁缺乏有反应。总体而言，我们的研究表明，目前已知的诱导持续性的机制中，cHsp60同源物的表达存在差异。