Lim Jae-Young, Cho Soo-Hun, Han Tai Ryoon, Paik Nam-Jong
Department of Rehabilitation Medicine, Seoul National University College of Medicine, Seoul, South Korea.
Clin Orthop Relat Res. 2004 Oct(427):120-6. doi: 10.1097/01.blo.0000142352.88039.33.
This study was done to determine the dose-responsiveness during the development of acute pressure-induced median neuropathy in rabbits and to develop a new animal model of acute carpal tunnel syndrome. Twenty-three rabbits were used. Carpal tunnel syndrome was induced by infusing a controlled saline solution into the carpal tunnel of rabbits using a 21-gauge needle under general anesthesia to elevate the carpal tunnel pressure. The changes in the amplitude and latency of the compound muscle action potential obtained by abductor pollicis recording were observed after a complete conduction block, and after the release of pressure at various pressure levels. Pressures greater than 30 mm Hg applied to the carpal tunnel caused a remarkable electrophysiologic change. A higher pressure level resulted in a shorter time required for a complete conduction block and also for recovery after the release of pressure. Complete conduction block occurred between 40 and 50 minutes at a pressure of 100 mm Hg. The degree of recovery after a conduction block was related inversely to the pressure-time integrals. Our animal model reflects the pathophysiology of acute carpal tunnel syndrome and shows a regular dose-responsiveness during the development of acute pressure-induced neuropathy.
本研究旨在确定兔急性压力性正中神经病变发展过程中的剂量反应性，并建立一种新的急性腕管综合征动物模型。使用了23只兔。在全身麻醉下，通过21号针头向兔腕管内注入生理盐水以升高腕管压力，从而诱发腕管综合征。在完全传导阻滞以及在不同压力水平解除压力后，观察通过拇短展肌记录获得的复合肌肉动作电位的幅度和潜伏期变化。施加于腕管的压力大于30 mmHg会引起显著的电生理变化。压力水平越高，完全传导阻滞所需时间越短，压力解除后恢复所需时间也越短。在100 mmHg压力下，40至50分钟内出现完全传导阻滞。传导阻滞后的恢复程度与压力 - 时间积分呈负相关。我们的动物模型反映了急性腕管综合征的病理生理学，并在急性压力性神经病变发展过程中显示出规律的剂量反应性。
