Biomechanics Laboratory, Department of Orthopedics, Mayo Clinic/Mayo Foundation, 200 First Street SW, Rochester, Minnesota 55905, USA.
J Orthop Res. 2010 May;28(5):652-6. doi: 10.1002/jor.21037.
The purpose of this study was to measure the compliance of the carpal tunnel in candidate animal models of carpal tunnel syndrome (CTS), by measuring the resistance when passing a tapered metal rod through the carpal tunnel. Forepaws from 10 dogs, 10 rabbits, and 10 rats with intact carpal tunnels, and 10 fresh frozen human wrist cadavers were used. The slopes of the linear part of the force-displacement curve (a measure of stiffness), normal force, and increasing area ratio (InAR) were significantly different among the four species (p<0.05). Post hoc analysis indicated that the mean slopes for the human carpal tunnel were the largest, indicating the least compliance, whereas those of the rat were the least (p<0.05). The features of the compliance for the dog carpal tunnel were closest to the human. The development of animal models of CTS should consider the compliance of the carpal tunnel, as it will be more difficult to increase pressure in a more compliant tunnel.
本研究旨在通过测量锥形金属棒穿过腕管时的阻力来测量腕管综合征（CTS）候选动物模型的腕管顺应性。使用了 10 只狗、10 只兔子和 10 只老鼠的完整腕管前爪，以及 10 个新鲜冷冻的人类腕骨尸体。力-位移曲线线性部分的斜率（衡量刚度）、法向力和增加面积比（InAR）在四种物种之间有显著差异（p<0.05）。事后分析表明，人类腕管的平均斜率最大，表明顺应性最小，而大鼠的斜率最小（p<0.05）。狗腕管的顺应性特征最接近人类。CTS 动物模型的开发应考虑腕管的顺应性，因为在顺应性更大的隧道中增加压力会更加困难。
