Tamber Harjit, Johansen Pål, Merkle Hans P, Gander Bruno
Institute of Pharmaceutical Sciences, ETH Zurich, ETH-Hoenggerberg, HCI, 8093 Zurich, Switzerland.
Adv Drug Deliv Rev. 2005 Jan 10;57(3):357-76. doi: 10.1016/j.addr.2004.09.002.
Biodegradable microspheres (MS) have proven to be very useful antigen delivery systems that are ingested by immunocompetent cells and provide prolonged antigen release and lasting immunity thanks to sustained release of the microencapsulated material. This review provides an applicable summary of different formulation routes for the purpose of producing safe, qualified and efficacious products of microencapsulated peptide and protein antigens. We have brought to attention, with case examples, not only the most common means of improving the quality of microsphere formulations, i.e., the use of stabilising additives, but also less commonly known and applied approaches, e.g., ion pairing, novel polymer systems, solid-state and other innovative microencapsulation methods.
可生物降解微球（MS）已被证明是非常有用的抗原递送系统，它们被免疫活性细胞摄取，并由于微囊化材料的持续释放而提供延长的抗原释放和持久的免疫力。本综述为生产安全、合格且有效的微囊化肽和蛋白质抗原产品的目的，提供了不同制剂途径的适用总结。我们通过实例不仅提请注意提高微球制剂质量的最常见方法，即使用稳定添加剂，还关注了鲜为人知且应用较少的方法，例如离子对、新型聚合物系统、固态及其他创新微囊化方法。
