Vaever Mette S, Licht Deborah M, Møller Lise, Perlt Dorthe, Jørgensen Age, Handest Peter, Parnas Josef
Department of Psychology, University of Copenhagen, Njalsgade 88, Copenhagen 2300, Denmark.
Schizophr Res. 2005 Jan 1;72(2-3):137-49. doi: 10.1016/j.schres.2004.04.001.
Formal thought disorder (FTD), a major symptom of schizophrenia, is known to aggregate in families. Our aim was to examine the specificity of FTD in the schizophrenia spectrum disorders and the hypothesized linear aggregation of FTD within pedigrees. Six individuals with a diagnosis of schizophrenia were identified in the Copenhagen High-Risk study and each pedigree was centered on one of the six original schizophrenic probands' nuclear families. The 329 pedigree members in the study were considered at risk for schizophrenia spectrum disorders because most were genetically related to the originating schizophrenic probands. The participants were administered the Copenhagen Interview of Functional Illness to determine diagnoses and the Thought Disorder Index (TDI) was used to assess FTD. Individuals with a schizophrenia diagnosis had higher global levels of FTD, exhibited more severe types of FTD, and had a qualitatively different type of FTD than did participants with other diagnoses or no mental illness. Individuals with Cluster A diagnoses exhibited more FTD and FTD similar in quality to participants with schizophrenia. These results support the construct of a spectrum of schizophrenia conditions. There was a generally high level of FTD in the pedigrees, in part due to assortative mating in this sample. However, there was no apparent pattern of linear aggregation of FTD within the families.
形式思维障碍（FTD）是精神分裂症的主要症状，已知在家族中具有聚集性。我们的目的是研究FTD在精神分裂症谱系障碍中的特异性，以及FTD在系谱中的假设线性聚集情况。在哥本哈根高危研究中确定了6名精神分裂症患者，每个系谱都以6名最初的精神分裂症先证者之一的核心家庭为中心。该研究中的329名系谱成员被认为有患精神分裂症谱系障碍的风险，因为大多数人与最初的精神分裂症先证者有遗传关系。对参与者进行了哥本哈根功能性疾病访谈以确定诊断，并使用思维障碍指数（TDI）来评估FTD。与其他诊断或无精神疾病的参与者相比，精神分裂症诊断患者的FTD总体水平更高，表现出更严重的FTD类型，且FTD的性质不同。A组诊断的个体表现出更多的FTD，且FTD的质量与精神分裂症患者相似。这些结果支持了精神分裂症谱系状况的概念。系谱中FTD的总体水平普遍较高，部分原因是该样本中的选型交配。然而，家族内FTD没有明显的线性聚集模式。
