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自体细胞刺激兔淋巴细胞的增殖反应。

The blastogenic response of rabbit lymphocytes stimulated with autologous cells.

作者信息

Milthorp P, Richter M

出版信息

Immunology. 1979 Mar;36(3):375-80.

PMID:155652
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1457580/
Abstract

Rabbit WBC and spleen cells respond with marked blastogenesis and mitosis when cultured with mitomycin-C treated autologous sacculus rotundus, appendix and Peyer's patches cells in the one-way rabbit mixed leucocyte reaction (MLR). A lesser response is observed using stimulating cells of the other lymphoid organs. The blastogenic response in the one-way 'autologous MLR' cannot be attributed to mitogenic factors released from the mitomycin-C treated stimulator cells since it is also observed in the 'two-way autologous MLR', using untreated stimulator cells. Several explanations are proposed to account for the 'autologous MLR'.

摘要

在单向兔混合淋巴细胞反应（MLR）中，当兔白细胞和脾细胞与经丝裂霉素-C处理的自体圆小囊、阑尾和派伊尔结细胞一起培养时，会出现明显的母细胞化和有丝分裂反应。使用其他淋巴器官的刺激细胞时观察到的反应较弱。单向“自体MLR”中的母细胞化反应不能归因于经丝裂霉素-C处理的刺激细胞释放的促有丝分裂因子，因为在使用未处理的刺激细胞的“双向自体MLR”中也观察到了这种反应。针对“自体MLR”提出了几种解释。

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IMMUNE RESPONSE AND MITOSIS OF HUMAN PERIPHERAL BLOOD LYMPHOCYTES IN VITRO.人外周血淋巴细胞在体外的免疫反应与有丝分裂
Science. 1963 Nov 29;142(3596):1185-7. doi: 10.1126/science.142.3596.1185.
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Differences between lymphocytes of leukemic and non-leukemic patients with respect to morphologic features, motility, and sensitivity to guinea pig serum.白血病患者与非白血病患者淋巴细胞在形态学特征、运动性及对豚鼠血清敏感性方面的差异。
Blood. 1961 Nov;18:561-71.
3
Mixed leukocyte stimulation of normal peripheral leukocytes by autologous lymphoblastoid cells.自体淋巴母细胞对正常外周白细胞的混合淋巴细胞刺激
Science. 1970 Nov 27;170(3961):989-90. doi: 10.1126/science.170.3961.989.
4
Isogeneic lymphocyte interaction: recognition of self antigens by cells of the neonatal thymus.同基因淋巴细胞相互作用：新生胸腺细胞对自身抗原的识别。
Proc Natl Acad Sci U S A. 1970 Oct;67(2):613-9. doi: 10.1073/pnas.67.2.613.
5
Mitomycin C inactivation of leukocytes in the mixed leukocyte culture.丝裂霉素C对混合白细胞培养中白细胞的灭活作用。
Transplantation. 1973 Mar;15(3):331-4. doi: 10.1097/00007890-197303000-00012.
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The response of rabbit lymphocytes to mitogens and alloantigens: evidence for T cell heterogeneity.兔淋巴细胞对有丝分裂原和同种异体抗原的反应：T细胞异质性的证据。
J Immunol. 1974 Dec;113(6):1780-92.
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In vitro induction of immunological memory against testicular autoantigens.体外诱导针对睾丸自身抗原的免疫记忆
Nature. 1977 May 26;267(5609):357-8. doi: 10.1038/267357a0.
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Lymphocyte interactions in autologous and allogeneic reactions.淋巴细胞在自体和异体反应中的相互作用。
Transplant Proc. 1977 Mar;9(1):789-92.
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