自体细胞诱导的淋巴细胞转化。V. 自体混合淋巴细胞反应中免疫记忆和特异性的产生。
Lymphocyte transformation induced by autologous cells. V. Generation of immunologic memory and specificity during the autologous mixed lymphocyte reaction.
作者信息
Weksler M E, Kozak R
出版信息
J Exp Med. 1977 Dec 1;146(6):1833-8. doi: 10.1084/jem.146.6.1833.
Abstract
Lymphocyte proliferation in vitro may follow antigen recognition and serve as a correlate of cell-mediated immunity. Lymphocyte proliferation can also be simulated by nonimmune mechanisms as, for example, following culture with plant lectin, lipopolysaccharides, or staphylococcal protein A (1). The autologous mixed lymphocyte reaction (MLR) refers to the proliferation of T lymphocytes cultured with autologous mon-T lymphocytes (2,3). The purpose of this study was to determine whether lymphocyte proliferation in the autologous MLR results from immune or nonimmune mechanisms. We have shown that the autologous MLR has two classical attributes of an immune phenomenon: memory and specificity.
摘要
体外淋巴细胞增殖可能继发于抗原识别，并可作为细胞介导免疫的一个相关指标。淋巴细胞增殖也可通过非免疫机制模拟，例如，在用植物凝集素、脂多糖或葡萄球菌蛋白A培养后（1）。自体混合淋巴细胞反应（MLR）指的是与自体单核T淋巴细胞一起培养的T淋巴细胞的增殖（2,3）。本研究的目的是确定自体MLR中的淋巴细胞增殖是由免疫机制还是非免疫机制引起的。我们已经表明，自体MLR具有免疫现象的两个经典特征：记忆性和特异性。
相似文献
1
Lymphocyte transformation induced by autologous cells. V. Generation of immunologic memory and specificity during the autologous mixed lymphocyte reaction.自体细胞诱导的淋巴细胞转化。V. 自体混合淋巴细胞反应中免疫记忆和特异性的产生。
J Exp Med. 1977 Dec 1;146(6):1833-8. doi: 10.1084/jem.146.6.1833.
2
Lymphocyte transformation induced by autologous cells.自体细胞诱导的淋巴细胞转化
Fed Proc. 1978 Aug;37(10):2370-3.
3
Lymphocyte transformation induced by autologous cells. X. Soluble factors that generate cytotoxic T lymphocytes.自体细胞诱导的淋巴细胞转化。X. 产生细胞毒性T淋巴细胞的可溶性因子。
J Exp Med. 1980 Aug 1;152(2 Pt 2):284s-291s.
4
Monoclonal antibody analysis of human T lymphocyte subpopulations exhibiting autologous mixed lymphocyte reaction.对表现出自体混合淋巴细胞反应的人T淋巴细胞亚群的单克隆抗体分析。
Proc Natl Acad Sci U S A. 1981 Aug;78(8):5096-8. doi: 10.1073/pnas.78.8.5096.
5
Lymphocyte transformation induced by autologous cells. IV. Human T-lymphocyte proliferation induced by autologous or allogeneic non-T lymphocytes.自体细胞诱导的淋巴细胞转化。IV. 自体或同种异体非T淋巴细胞诱导的人T淋巴细胞增殖。
J Exp Med. 1976 May 1;143(5):1042-54. doi: 10.1084/jem.143.5.1042.
6
7
8
Regulation of the growth of Epstein-Barr virus-infected B cells. I. Growth regression by E rosetting cells from VCA-positive donors is a combined effect of autologous mixed leukocyte reaction and activation of T8+ memory cells.爱泼斯坦-巴尔病毒感染的B细胞生长的调节。I. 来自VCA阳性供体的E花环形成细胞导致的生长消退是自体混合淋巴细胞反应和T8 + 记忆细胞激活的联合效应。
J Immunol. 1985 Apr;134(4):2287-93.
9
Induction of suppressor activity in the autologous mixed lymphocyte reaction and in cultures with concanavalin A.在自体混合淋巴细胞反应及伴刀豆球蛋白A的培养物中诱导抑制活性。
J Clin Invest. 1979 Dec;64(6):1608-13. doi: 10.1172/JCI109622.
引用本文的文献
1
Human CD4(+) effector T lymphocytes generated upon TCR engagement with self-peptides respond defectively to IL-7 in their transition to memory cells.当 T 细胞受体与自身肽结合后产生的人 CD4(+)效应 T 淋巴细胞在向记忆细胞过渡时，对 IL-7 的反应存在缺陷。
Cell Mol Immunol. 2013 May;10(3):261-74. doi: 10.1038/cmi.2012.71. Epub 2013 Mar 4.
2
Activation-induced FoxP3 expression regulates cytokine production in conventional T cells stimulated with autologous dendritic cells.激活诱导的FoxP3表达调节用自体树突状细胞刺激的常规T细胞中的细胞因子产生。
Clin Vaccine Immunol. 2012 Oct;19(10):1583-92. doi: 10.1128/CVI.00308-12. Epub 2012 Aug 1.
3
4
Chronic lymphocytic leukemia: temporal changes in numbers of T-lymphocytes.慢性淋巴细胞白血病：T淋巴细胞数量的时间变化
Can Med Assoc J. 1980 Apr 19;122(8):914-6.
5
Generation of suppressor cells in the autologous mixed lymphocyte reaction.自体混合淋巴细胞反应中抑制细胞的产生。
Clin Exp Immunol. 1981 Oct;46(1):185-95.
6
Role of individual chains of HLA-DR antigens in activation of T cells induced by alloantigens.HLA - DR抗原各条链在同种抗原诱导的T细胞活化中的作用。
Immunogenetics. 1981;14(3-4):309-22. doi: 10.1007/BF00342200.
7
Responder cells in the human autologous mixed lymphocyte reaction.人类自体混合淋巴细胞反应中的反应细胞。
J Clin Invest. 1981 Dec;68(6):1601-4. doi: 10.1172/jci110416.
8
The suppressive effects of monocytes in the autologous mixed lymphocyte reaction.单核细胞在自体混合淋巴细胞反应中的抑制作用。
Immunology. 1981 Dec;44(4):653-9.
9
Factors influencing the autologous mixed lymphocyte reaction in rats: effect of xenogeneic serum protein.影响大鼠自体混合淋巴细胞反应的因素：异种血清蛋白的作用。
Immunology. 1981 Nov;44(3):499-507.
10
Monoclonal antibody analysis of human T lymphocyte subpopulations exhibiting autologous mixed lymphocyte reaction.对表现出自体混合淋巴细胞反应的人T淋巴细胞亚群的单克隆抗体分析。
Proc Natl Acad Sci U S A. 1981 Aug;78(8):5096-8. doi: 10.1073/pnas.78.8.5096.
本文引用的文献
1
Histocompatibility matching. VI. Miniaturization of the mixed leukocyte culture test: a preliminary report.组织相容性匹配。VI. 混合淋巴细胞培养试验的小型化：初步报告。
Transplantation. 1971 Mar;11(3):268-73. doi: 10.1097/00007890-197103000-00005.
2
Lymphocyte transformation induced by autologous cells. IV. Human T-lymphocyte proliferation induced by autologous or allogeneic non-T lymphocytes.自体细胞诱导的淋巴细胞转化。IV. 自体或同种异体非T淋巴细胞诱导的人T淋巴细胞增殖。
J Exp Med. 1976 May 1;143(5):1042-54. doi: 10.1084/jem.143.5.1042.
3
Autologous stimulation of human lymphocyte subpopulation.人淋巴细胞亚群的自体刺激
J Exp Med. 1975 Nov 1;142(5):1327-33. doi: 10.1084/jem.142.5.1327.
4
HL-A LD (lymphocyte defined) typing: a rapid assay with primed lymphocytes.HL-A LD（淋巴细胞定义）分型：一种用致敏淋巴细胞的快速检测法。
Science. 1975 Jun 27;188(4195):1308-10. doi: 10.1126/science.124948.
5
Specific transplantation tolerance induced by autoimmunization against the individual's own, naturally occurring idiotypic, antigen-binding receptors.通过针对个体自身天然存在的独特型抗原结合受体进行自身免疫诱导的特异性移植耐受。
J Exp Med. 1976 Dec 1;144(6):1438-57. doi: 10.1084/jem.144.6.1438.
Zotero 插件