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1例急性髓系白血病完全缓解期出现粒细胞肉瘤,伴有累及喉和鼻咽的多发肿块。

A case of granulocytic sarcoma during complete remission of acute myeloid leukemia with multiple masses involving the larynx and nasopharynx.

作者信息

Ozçelik Tülay, Ali Ridvan, Ozkalemkaş Fahir, Ozkocaman Vildan, Coşkun Hakan, Erişen Levent, Filiz Gülaydan

机构信息

Department of Internal Medicine, Division of Hematology, Medicine Faculty of Uludağ University, Bursa, Turkey.

出版信息

Kulak Burun Bogaz Ihtis Derg. 2003 Dec;11(6):183-8.

Abstract

A thirty-seven-year-old male patient presented with dysphagia and hoarseness six months after complete remission of acute myeloid leukemia (AML-M0), which had been treated with chemotherapy. Physical examination revealed left vocal cord paralysis and involvement of the 9th, 10th, and 12th cranial nerves. Sagittal and axial magnetic resonance scans of the nasopharynx and neck showed a mass in the left retropharyngeal and perivertebral regions, 6x4 cm in size; another mass in the left vallecula, and infiltration of the right preepiglottic tissue by another mass of 2 cm. There was no bone marrow involvement. A diagnosis of granulocytic sarcoma without leukemia relapse was made and the FLAG-Ida regimen was administered, after which partial regression of the masses was observed. However, the patient died due to a pulmonary infection on the 17th day of chemotherapy.

摘要

一名37岁男性患者,急性髓系白血病(AML-M0)经化疗完全缓解6个月后,出现吞咽困难和声音嘶哑。体格检查发现左侧声带麻痹,第9、10和12对脑神经受累。鼻咽部和颈部的矢状位和轴位磁共振扫描显示,左咽后和椎旁区域有一肿块,大小为6×4 cm;左会厌谷有另一肿块,还有一2 cm大小的肿块浸润右会厌前组织。无骨髓受累。诊断为无白血病复发的粒细胞肉瘤,并给予FLAG-Ida方案治疗,之后观察到肿块部分消退。然而,患者在化疗第17天因肺部感染死亡。

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