Pommepuy Isabelle, Roblet Denis, Blaise Sophie, Delage-Corre Manuela, Bonnetblanc Jean-Marie, Fayol Jacqueline, Labrousse François
Service d'Anatomie Pathologique, France.
Ann Pathol. 2004 Sep;24(4):368-70. doi: 10.1016/s0242-6498(04)93986-7.
Onychomatricoma is a rare fibroepithelial lesion of the nail matrix with peculiar clinical and histological features. Clinically, it is characterized by a longitudinal band of yellow thickening of the nail plate with transverse overcurvature and splinter hemorrhages. Nail avulsion exposes a villous tumor of the matrix with filamentous digitations extending into multiple holes of the nail plate. Histologically, a thick keratogenous zone forms a thickened nail plate. The lesion in its proximal portion is characterized by deep epithelial invaginations and by a stroma organized in two layers. The distal zone corresponds to multiple fibroepithelial projections extending into the nail plate. The diagnosis can be difficult in the presence of misleading clinical features or when the specimen is incomplete or examined with an improper orientation. Surgical resection is the recommended treatment.
甲床瘤是一种罕见的甲床纤维上皮性病变，具有独特的临床和组织学特征。临床上，其特征为甲板出现纵向黄色增厚带，伴有横向过度弯曲和裂片样出血。拔甲后可见甲床呈绒毛状肿瘤，有丝状指状突起延伸至甲板的多个小孔中。组织学上，一个厚的角质形成区形成增厚的甲板。病变近端部分的特征是上皮深陷以及间质分为两层。远端区域对应多个延伸至甲板的纤维上皮性突起。当存在误导性临床特征、标本不完整或检查方向不正确时，诊断可能会很困难。推荐的治疗方法是手术切除。
