Nakamura H, Moroji T, Nakamura H, Nohara S, Okada A
Department of Public Health, School of Medicine, Kanazawa University.
Nihon Eiseigaku Zasshi. 1992 Feb;46(6):1095-103. doi: 10.1265/jjh.46.1095.
In order to clarify the involvement of cerebral 3,4-dihydroxyphenylacetic acid (DOPAC) and vasoactive intestinal polypeptide (VIP) in whole-body vibration stress, DOPAC and VIP-like immunoreactivity (VIP-LI) in various discrete brain regions of rats exposed to whole-body vibration (4G, 20 Hz, 90 min) were assayed. The results showed that the whole-body vibration increased the DOPAC level in the frontal cortex and nucleus accumbens, but did not induce a concurrent change of VIP-LI in these regions. VIP-LI was significantly increased in the amygdala, and decreased in the hippocampus, accompanied by no significant change of DOPAC. These results show that whole-body vibration affects cerebral VIP neuron systems in addition to its nonspecific action, i.e. the activation of mesofrontal and mesoaccumbens dopamine neuron systems. It is assumed that the amygdalofugal VIP neuronal system is involved in the regulation of hypothalamic and pituitary hormone secretions, and that VIP in the hippocampus plays a part in modulating the blood circulation in the cortex in whole-body vibration stress.
为了阐明脑内3,4-二羟基苯乙酸（DOPAC）和血管活性肠肽（VIP）在全身振动应激中的作用，对暴露于全身振动（4G，20Hz，90分钟）的大鼠不同离散脑区中的DOPAC和VIP样免疫反应性（VIP-LI）进行了测定。结果表明，全身振动增加了额叶皮质和伏隔核中的DOPAC水平，但并未引起这些区域中VIP-LI的同时变化。杏仁核中的VIP-LI显著增加，而海马体中的VIP-LI减少，同时DOPAC无显著变化。这些结果表明，全身振动除了其非特异性作用，即中额叶和中伏隔核多巴胺神经元系统的激活外，还影响脑内VIP神经元系统。据推测，杏仁核传出VIP神经元系统参与下丘脑和垂体激素分泌的调节，海马体中的VIP在全身振动应激中对皮质血液循环的调节中起作用。
