Yu You, He Guang-Zhao, Wu Yi, Huang Chong-Ben
Department of Plastic Surgery, Emergency Medical Center of Chongqing, Chongqing 400014, China.
Zhonghua Zheng Xing Wai Ke Za Zhi. 2004 Jul;20(4):271-3.
To study the expression of alpha5beta1 integrin in the abnormal scars and its role and significance in the formation and development of abnormal scars.
The expression of alpha5beta1 integrin was observed in hypertrophic scar (15 samples), keloid (15 samples) and normal skin (10 samples) with SP immunohistochemical method and colloidal gold immuno-electron microscopic technique. The data were semi-quantitatively analyzed.
The expression levels of alpha5beta1 integrin in the fibroblasts of keloids and hypertrophic scars were higher than normal skin; the expression of alpha5beta1 integrin in the fibroblasts of keloids was higher than hypertrophic scars (P < 0.01).
The alpha5beta1 integrin appears to have close relation to the formation and development of abnormal scars. To find a way to decrease the expression level of alpha5beta1 integrin in fibroblasts may be a new approach to inhibit scar hypertrophy.
研究α5β1整合素在病理性瘢痕中的表达情况及其在病理性瘢痕形成和发展中的作用及意义。
采用SP免疫组织化学方法及胶体金免疫电镜技术观察15例增生性瘢痕、15例瘢痕疙瘩及10例正常皮肤中α5β1整合素的表达情况，并进行半定量分析。
瘢痕疙瘩及增生性瘢痕成纤维细胞中α5β1整合素的表达水平高于正常皮肤；瘢痕疙瘩成纤维细胞中α5β1整合素的表达高于增生性瘢痕（P<0.01）。
α5β1整合素似乎与病理性瘢痕的形成和发展密切相关。寻找降低成纤维细胞中α5β1整合素表达水平的方法可能是抑制瘢痕增生的新途径。
