Alper Arnold B, Chen Wei, Yau Lillian, Srinivasan Sathanur R, Berenson Gerald S, Hamm L Lee
Department of Internal Medicine, Tulane Hypertension and Renal Center of Excellence, Tulane University Health Sciences Center, New Orleans, La 70112, USA.
Hypertension. 2005 Jan;45(1):34-8. doi: 10.1161/01.HYP.0000150783.79172.bb. Epub 2004 Nov 29.
Uric acid has been proposed as an important risk factor in the development of primary hypertension in humans. However, limited information is available linking childhood uric acid levels and blood pressure levels in adulthood. This study examined 334 whites and 243 blacks enrolled in the Bogalusa Heart Study as children aged 5 to 17 years and as adults aged 18 to 35 years. The average follow-up period was 12 years. Childhood uric acid was significantly correlated with childhood and adult blood pressure, both systolic and diastolic. In a multivariate regression analysis, adjusting for age, sex, race, childhood body mass index, childhood uric acid levels, and change in levels of uric acid were significant predictors of adult diastolic blood pressure, whereas change in uric acid was a significant predictor of adult systolic blood pressures. In conclusion, elevated childhood serum uric acid levels are associated with increased blood pressure beginning in childhood and higher blood pressure levels that persist into adulthood, in males and females, whites and blacks, suggesting that early elevations in serum uric acid levels may play a key role in the development of human hypertension.
尿酸已被认为是人类原发性高血压发生发展的一个重要危险因素。然而，关于儿童期尿酸水平与成年期血压水平之间的关联，现有信息有限。本研究对参加博加卢萨心脏研究的334名白人儿童和243名黑人儿童进行了调查，这些儿童年龄在5至17岁之间，成年后年龄在18至35岁之间。平均随访期为12年。儿童期尿酸与儿童期及成年期的血压（收缩压和舒张压）均显著相关。在多变量回归分析中，校正年龄、性别、种族、儿童期体重指数后，儿童期尿酸水平及尿酸水平变化是成年舒张压的显著预测因素，而尿酸变化是成年收缩压的显著预测因素。总之，儿童期血清尿酸水平升高与儿童期血压升高以及持续至成年期的较高血压水平相关，无论男性还是女性、白人还是黑人，这表明血清尿酸水平早期升高可能在人类高血压的发生发展中起关键作用。
