Gallant Amanda J, Patrick Brian O, MacLachlan Mark J
Department of Chemistry, University of British Columbia, 2036 Main Mall, Vancouver, BC, Canada V6T 1Z1.
J Org Chem. 2004 Dec 10;69(25):8739-44. doi: 10.1021/jo049197u.
During investigations of 5, a [3 + 3] Schiff-base macrocycle with six imines, a partially reduced Schiff-base macrocycle, 6, possessing one CH(2)NH and five imine groups was obtained. Control experiments and deuterium labeling indicate that the macrocycle is reduced by a benzimidazoline generated during the reaction. Benzimidazolines may be convenient reagents for the mild and selective reduction of imines.
在对一种具有六个亚胺基的[3 + 3]席夫碱大环化合物5进行研究时，得到了一种部分还原的席夫碱大环化合物6，它含有一个CH(2)NH和五个亚胺基。对照实验和氘标记表明，该大环化合物是由反应过程中生成的苯并咪唑啉还原得到的。苯并咪唑啉可能是用于温和且选择性地还原亚胺的便利试剂。
