Kusunoki Takeshi, Cureoglu Sebahattin, Schachern Patricia A, Baba Kazuyasu, Kariya Shin, Paparella Michael M
International Hearing Foundation, Minneapolis, Minnesota, USA.
Otolaryngol Head Neck Surg. 2004 Dec;131(6):897-903. doi: 10.1016/j.otohns.2004.05.022.
Previous reports on aging of human cochlea included subjects with ear diseases or ototoxic drugs. We studied spiral ganglion cells, hair cells, and lateral wall of cochlea from subjects without ear disease or ototoxic drugs.
This study included 39 temporal bones from 24 subjects aged 1 day to 86 years. We assessed standard cytocochleograms, mean loss of fibrocytes in spiral ligament, and areas of stria vascularis.
Losses of outer hair cells and fibrocytes were significantly greater in children, adults, and the elderly compared with infants. Spiral ganglion cell loss was significantly greater in adults and elderly compared with infants and children. Areas of stria vascularis of infants were significantly larger than the elderly.
Degenerative changes of outer hair cells occur in children but spiral ganglion cells remain the same until around 20 years. Degeneration of stria vascularis due to aging appears to be slower than spiral ligament.
C.
先前关于人类耳蜗衰老的报告纳入了患有耳部疾病或使用耳毒性药物的受试者。我们研究了无耳部疾病或未使用耳毒性药物的受试者的螺旋神经节细胞、毛细胞和耳蜗外侧壁。
本研究纳入了来自24名年龄从1天至86岁受试者的39块颞骨。我们评估了标准细胞耳蜗图、螺旋韧带中纤维细胞的平均损失以及血管纹面积。
与婴儿相比，儿童、成人和老年人的外毛细胞和纤维细胞损失明显更大。与婴儿和儿童相比，成人和老年人的螺旋神经节细胞损失明显更大。婴儿的血管纹面积明显大于老年人。
儿童期即出现外毛细胞的退行性变化，但螺旋神经节细胞在20岁左右之前保持不变。血管纹因衰老而发生的退变似乎比螺旋韧带更慢。
C级。
