Nomiya Rie, Nomiya Shigenobu, Kariya Shin, Okano Mitsuhiro, Morita Norimasa, Cureoglu Sebahattin, Schachern Patricia A, Nishizaki Kazunori, Paparella Michael M
Otitis Media Research Center, Department of Otolaryngology, University of Minnesota, Minneapolis, Minnesota 55455, USA.
Otol Neurotol. 2008 Dec;29(8):1193-7. doi: 10.1097/MAO.0b013e31818a0906.
To disclose the histopathologic findings of the cochlea in young adults with generalized arteriosclerosis.
It is well known that arteriosclerosis begins and progresses during childhood. Although the relationship between arteriosclerosis and auditory function in elderly people was examined in many reports, the histopathologic effect of arteriosclerosis on the cochlea in young adults has not been studied.
This study involved quantitative analysis, including the number of spiral ganglion cells, the loss of cochlear outer hair cells, and the areas of stria vascularis and spiral ligament. It included 10 temporal bones from 6 subjects with generalized arteriosclerosis and 10 age-matched normal control temporal bones from 7 subjects.
The mean number of spiral ganglion cells in the cochlea with generalized arteriosclerosis was significantly lower than that in normal controls in the basal turn. The mean loss of outer hair cells in the cochlea with generalized arteriosclerosis was significantly greater than that of normal controls in the basal and apical turns. The stria vascularis and spiral ligament were severely atrophic, with generalized arteriosclerosis in the basal turn. There was no significant difference in the thickness of the spiral modiolar artery between generalized arteriosclerosis and normal controls.
Degeneration of the cochlea, especially in the basal turn, was already apparent in young adults with generalized arteriosclerosis.
揭示患有全身性动脉硬化的年轻成年人耳蜗的组织病理学发现。
众所周知，动脉硬化始于儿童期并在儿童期进展。尽管许多报告研究了老年人动脉硬化与听觉功能之间的关系，但尚未研究动脉硬化对年轻成年人耳蜗的组织病理学影响。
本研究涉及定量分析，包括螺旋神经节细胞数量、耳蜗外毛细胞损失以及血管纹和螺旋韧带的面积。研究包括来自6名患有全身性动脉硬化受试者的10块颞骨以及来自7名年龄匹配正常对照受试者的10块颞骨。
患有全身性动脉硬化的耳蜗中螺旋神经节细胞的平均数量在蜗底显著低于正常对照。患有全身性动脉硬化的耳蜗中外毛细胞的平均损失在蜗底和蜗顶显著大于正常对照。血管纹和螺旋韧带严重萎缩，在蜗底存在全身性动脉硬化。全身性动脉硬化与正常对照之间螺旋蜗轴动脉的厚度无显著差异。
患有全身性动脉硬化的年轻成年人耳蜗已经出现退化，尤其是在蜗底。
