van Zeijl Jan H, Mullaart Reinier A, Borm George F, Galama Jochem M D
Department of Medical Microbiology, Public Health Laboratory Friesland, Leeuwarden, The Netherlands.
J Pediatr. 2004 Dec;145(6):800-5. doi: 10.1016/j.jpeds.2004.08.075.
To investigate the association of viral infections and febrile seizures (FS).
From April 1998 to April 2002, a prospective, population-based study was carried out among general practitioners to assess the incidence of FS in their practices. Data thus obtained were compared with the incidence of common viral infections recorded in a national registry. Poisson regression analysis was performed to investigate whether the season or the type of infection was associated with the variation observed in FS incidence.
Throughout the 4-year period, 267 of 303 (88%) of general practitioners in the Dutch province of Friesland participated in the study. The estimated observation period was approximately 160,000 patient-years. We registered 654 cases of FS in 429 children. The estimated incidence of FS was 2.4 in 1000 patient-years. Poisson regression analysis revealed a positive correlation between recurrent FS and influenza A ( P = .01).
Our study suggests a relation between recurrent FS and influenza A. Influenza vaccination should be considered in all children with a history of FS.
研究病毒感染与热性惊厥（FS）之间的关联。
1998年4月至2002年4月，在全科医生中开展了一项基于人群的前瞻性研究，以评估其诊所中FS的发病率。将由此获得的数据与国家登记处记录的常见病毒感染发病率进行比较。进行泊松回归分析，以研究季节或感染类型是否与FS发病率的观察变化相关。
在整个4年期间，荷兰弗里斯兰省303名全科医生中的267名（88%）参与了研究。估计观察期约为160,000患者年。我们在429名儿童中记录了654例FS病例。FS的估计发病率为每1000患者年2.4例。泊松回归分析显示复发性FS与甲型流感之间存在正相关（P = 0.01）。
我们的研究表明复发性FS与甲型流感之间存在关联。所有有FS病史的儿童都应考虑接种流感疫苗。
