热性惊厥：病因、患病率及地域差异
Febrile seizures: etiology, prevalence, and geographical variation.
作者信息
Delpisheh Ali, Veisani Yousef, Sayehmiri Kourosh, Fayyazi Afshin
机构信息
Prevention of Psychosocial Injuries Research Center, Ilam University of Medical Sciences, Ilam, Iran ; Department of Clinical Epidemiology, Ilam University of Medical Sciences, Ilam, Iran.
Department of Clinical Epidemiology, Ilam University of Medical Sciences, Ilam, Iran ; The Student Research Committee, Ilam University of Medical Sciences, Ilam, Iran.
出版信息
Iran J Child Neurol. 2014 Summer;8(3):30-7.
OBJECTIVE
Febrile seizures (FSs) are the most common neurological disorder observed in the pediatric age group. The present study provides information about epidemiological and clinical characteristics as well as risk factors associated with FS among Iranian children.
MATERIALS & METHODS: On the computerized literature valid databases, the FS prevalence and 95% confidence intervals were calculated using a random effects model. A metaregression analysis was introduced to explore heterogeneity between studies. Data manipulation and statistical analyses were performed using Stata10.
RESULTS
The important viral or bacterial infection causes of FSs were; recent upper respiratory infection 42.3% (95% CI: 37.2%-47.4%), gastroenteritis21.5% (95% CI: 13.6%-29.4%), and otitis media nfections15.2% (95% CI: 9.8%- 20.7%) respectively. The pooled prevalence rate of FS among other childhood convulsions was 47.9% (95% CI: 38.8-59.9%). The meta-regression analysis showed that the sample size does not significantly affect heterogeneity for the factor 'prevalence FS'.
CONCLUSION
Almost half of all childhood convulsions among Iranian children are associated with Febrile seizure.
目的
热性惊厥（FSs）是小儿年龄组中最常见的神经系统疾病。本研究提供了有关伊朗儿童FSs的流行病学和临床特征以及相关危险因素的信息。
材料与方法
在计算机化文献有效数据库中，使用随机效应模型计算FSs患病率及95%置信区间。引入元回归分析以探讨研究间的异质性。使用Stata10进行数据处理和统计分析。
结果
FSs的重要病毒或细菌感染病因分别为：近期上呼吸道感染42.3%（95%CI：37.2%-47.4%）、胃肠炎21.5%（95%CI：13.6%-29.4%）和中耳炎感染15.2%（95%CI：9.8%-20.7%）。在其他儿童惊厥中FSs的合并患病率为47.9%（95%CI：38.8-59.9%）。元回归分析表明，样本量对“FSs患病率”这一因素的异质性无显著影响。
结论
伊朗儿童中几乎一半的儿童惊厥与热性惊厥有关。
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