[巴雷特食管]
[Barrett's esophagus].
作者信息
Kauer W K H, Stein H J, Dittler H J, Siewert J R
机构信息
Chirurgische Klinik und Poliklinik, Klinikum rechts der Isar der Technischen Universität München.
出版信息
Chirurg. 2005 Mar;76(3):258-62. doi: 10.1007/s00104-004-0952-3.
INTRODUCTION
It is widely accepted that long segments of Barrett's esophagus are caused by end-stage gastroesophageal reflux disease (GERD), but little is known about the correlation of severity of GERD and extent of metaplasia.
METHODS
Twenty normal volunteers and 142 patients with different extent of intestinal metaplasia (39 with intestinal metaplasia limited to the esophagogastric junction, 48 with short segments of Barrett's esophagus, and 55 with long segments) underwent manometry and combined pH-bilirubin monitoring.
RESULTS
The extent of intestinal metaplasia correlated to the exposition of gastric and duodenal juice in the esophagus and inversely with a competent lower esophageal sphincter.
CONCLUSIONS
The extent of intestinal metaplasia is related to the severity of GERD.
引言
人们普遍认为，长段巴雷特食管是由终末期胃食管反流病（GERD）引起的，但对于GERD的严重程度与化生范围之间的相关性却知之甚少。
方法
20名正常志愿者和142例不同程度肠化生患者（39例肠化生局限于食管胃交界处，48例为短段巴雷特食管，55例为长段）接受了测压和联合pH-胆红素监测。
结果
肠化生的范围与食管中胃液和十二指肠液的暴露相关，与食管下括约肌功能正常呈负相关。
结论
肠化生的范围与GERD的严重程度相关。
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