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某些植物制品对人淋巴细胞培养物中遗传毒性损伤的改善作用。

Amelioration of genotoxic damage by certain phytoproducts in human lymphocyte cultures.

作者信息

Ahmad Md Sultan, Afzal Mohd

机构信息

Section of Genetics, Department of Zoology, Aligarh Muslim University, Aligarh 202002 India.

出版信息

Chem Biol Interact. 2004 Oct 15;149(2-3):107-15. doi: 10.1016/j.cbi.2004.06.008.

Abstract

The antigenotoxic effect of some phytoproducts like carotenoid (beta-carotene), curcumin, ascorbic acid and flavonoid (genistein)was demonstrated on the genotoxicity induced by hydrocortisone. Human lymphocyte cultures were studied for the induction of chromosomal aberrations, sister chromatid exchanges and effect on cell cycle kinetics with or without the presence of metabolic activation (S9 mix). The phytoproducts were studied in two most effective doses viz. carotenoid (0.5 and 0.7 microM), curcumin (15 and 25 microM), ascorbic acid (60 and 80 microM) and flavonoid (25 and 40 microM) in 24, 48 and 72 h cultures, and they were found to reduce chromosomal aberrations, sister chromatid exchange and increase replication index. The present study showed that the ascorbic acid and curcumin were more effective than carotenoid and flavonoid, though all provide protection against the genotoxicity of hydrocortisone.

摘要

一些植物产物如类胡萝卜素(β-胡萝卜素)、姜黄素、抗坏血酸和类黄酮(染料木黄酮)对氢化可的松诱导的遗传毒性具有抗遗传毒性作用。研究了人淋巴细胞培养物中有无代谢活化(S9混合物)时染色体畸变、姐妹染色单体交换的诱导情况以及对细胞周期动力学的影响。在24、48和72小时的培养中,以两种最有效的剂量研究了这些植物产物,即类胡萝卜素(0.5和0.7微摩尔)、姜黄素(15和25微摩尔)、抗坏血酸(60和80微摩尔)和类黄酮(25和40微摩尔),发现它们可减少染色体畸变、姐妹染色单体交换并增加复制指数。本研究表明,抗坏血酸和姜黄素比类胡萝卜素和类黄酮更有效,尽管它们都能提供针对氢化可的松遗传毒性的保护作用。

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