来自黄龙胆的单胺氧化酶抑制剂。
Monoamine oxidase inhibitors from Gentiana lutea.
作者信息
Haraguchi Hiroyuki, Tanaka Yasumasa, Kabbash Amal, Fujioka Toshihiro, Ishizu Takashi, Yagi Akira
机构信息
Faculty of Life Science and Biotechnology, Fukuyama University, Gakuen-cho, Fukuyama 729-0292, Japan.
出版信息
Phytochemistry. 2004 Aug;65(15):2255-60. doi: 10.1016/j.phytochem.2004.06.025.
Three monoamine oxidase (MAO) inhibitors were isolated from Gentiana lutea. Their structures were elucidated to be 3-3''linked-(2'-hydroxy-4-O-isoprenylchalcone)-(2'''-hydroxy-4''-O-isoprenyldihydrochalcone) (1), 2-methoxy-3-(1,1'-dimethylallyl)-6a,10a-dihydrobenzo(1,2-c)chroman-6-one and 5-hydroxyflavanone. These compounds, and the hydrolysis product of 1, displayed competitive inhibitory properties against MAO-B which was more effective than MAO-A.
从黄龙胆中分离出三种单胺氧化酶（MAO）抑制剂。它们的结构被确定为3-3''连接的-(2'-羟基-4-O-异戊烯基查耳酮)-(2'''-羟基-4''-O-异戊烯基二氢查耳酮)（1）、2-甲氧基-3-(1,1'-二甲基烯丙基)-6a,10a-二氢苯并(1,2-c)色满-6-酮和5-羟基黄酮。这些化合物以及1的水解产物对MAO-B表现出竞争性抑制特性，其对MAO-B的抑制作用比对MAO-A更有效。
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