卡杜纳二区新生儿眼炎的病例对照研究：病原体及其抗生素敏感性

A case control study of ophthalmia Neonatorum in Kaduna II: causative agents and their antibiotic sensitivity.

作者信息

Olatunji F O

机构信息

Department of Ophthalmology University of Ilorin Teaching Hospital, Ilorin, Kwara State, Nigeria.

出版信息

West Afr J Med. 2004 Jul-Sep;23(3):215-20. doi: 10.4314/wajm.v23i3.28124.

DOI:10.4314/wajm.v23i3.28124

PMID:15587832

Abstract

AIM

To identify the causative agents of ophthalmia neonatorum and their antibiotic sensitivity in the hospitals of study.

PATIENTS AND METHODS

A case-control study of ophthalmia neonatorum was carried out in 6 hospitals in Kaduna metropolis in northern Nigeria. Two hundred cases were matched with two hundred controls.

RESULTS

The male to female ratio was 1.1:1. The mean age of the patients was 8.9 days, and range was birth to 28 days. The age at the onset of the symptoms was birth to 27 days with a mean of 3.9 days. The most common pathogen isolated in this study was Staphylococcus aureus, both in cases (69.7%) and in controls (48%). Only one case of Neisseria gonorrhoea was found. Thirteen and four E. coli were isolated from cases and control while 7 and 31 Staphylococcus epidermidis were isolated from cases and controls respectively. Giemsa staining carried out in only 3 out of the 6 hospitals yielded 9 and 3 isolates of Chlamydia trachomatis in cases and controls respectively. The percentage sensitivity of Staphylococcus aureus to penicillin, chloramphenicol, tetracycline, erythromycin and gentamicin were 3, 73, 37, 59 and 77 respectively. The corresponding sensitivity of E. coli to the above antibiotics was 0, 69, 46, 10 and 62 respectively.

CONCLUSION

Most of the cases of ophthalmia neonatorum are mild.

摘要

目的

确定研究医院中新生儿眼炎的病原体及其抗生素敏感性。

患者与方法

在尼日利亚北部卡杜纳市的6家医院开展了一项新生儿眼炎病例对照研究。200例病例与200例对照进行匹配。

结果

男女比例为1.1:1。患者的平均年龄为8.9天，范围为出生至28天。症状出现时的年龄为出生至27天，平均为3.9天。本研究中分离出的最常见病原体是金黄色葡萄球菌，病例组（69.7%）和对照组（48%）均如此。仅发现1例淋病奈瑟菌。分别从病例组和对照组中分离出13株和4株大肠杆菌，同时分别从病例组和对照组中分离出7株和31株表皮葡萄球菌。在6家医院中只有3家进行了吉姆萨染色，病例组和对照组分别检出9株和3株沙眼衣原体。金黄色葡萄球菌对青霉素、氯霉素、四环素、红霉素和庆大霉素的敏感率分别为3%、73%、37%、59%和77%。大肠杆菌对上述抗生素的相应敏感率分别为0%、69%、46%、10%和62%。