Kasanah Noer, Hamann Mark T
Department of Pharmacognosy, National Center for Natural Product Research, School of Pharmacy, The University of Mississippi, MS 38677, USA.
Curr Opin Investig Drugs. 2004 Aug;5(8):827-37.
Antibiotics remain essential tools in the control of infectious diseases. With the emergence of new diseases, resistant forms of diseases such as tuberculosis and malaria, as well as the emergence of multidrug-resistant bacteria, it has become essential to develop novel antibiotics. Development of the existing antibiotics involved three strategies, including discovery of new target sites, modification of existing antibiotic structures, and the identification of new resources for novel antibiotics. Marine microorganisms have clearly become an essential new resource in the discovery of new antibiotic leads.
抗生素仍然是控制传染病的重要工具。随着新疾病的出现、结核病和疟疾等耐药性疾病形式的出现以及多重耐药细菌的出现，开发新型抗生素变得至关重要。现有抗生素的开发涉及三种策略，包括发现新的靶点、修饰现有抗生素结构以及鉴定新型抗生素的新资源。海洋微生物显然已成为发现新抗生素先导物的重要新资源。
