Reichenbach H, Höfle G
Gesellschaft für Biotechnologische Forschung, Microbial Secondary Metabolites, Mascheroder Weg 1, D-3300 Braunschweig, Germany.
Biotechnol Adv. 1993;11(2):219-77. doi: 10.1016/0734-9750(93)90042-l.
New chemical structures with proven biological activity still are badly needed for a host of applications and are intensively screened for. Suitable compounds may be used as such, or in the form of their derivatives or, equally important, may serve as lead compounds for designing synthetic analogs. One way to new compounds is the exploitation of new producer organisms. During the past 15 years the myxobacteria have been shown in our laboratories to be a rich source of novel secondary metabolites, many of the compounds showing interesting and sometimes unique mechanisms of action. About 50 basic structures and nearly 300 structural variants have been elucidated, and almost all of them turned out to be new compounds. Several myxobacterial substances may have a good chance of an application.
对于许多应用而言，仍迫切需要具有已证实生物活性的新化学结构，并正在对此进行密集筛选。合适的化合物可以直接使用，或以其衍生物的形式使用，或者同样重要的是，可以用作设计合成类似物的先导化合物。获得新化合物的一种方法是开发新的产生生物。在过去的15年中，我们实验室已证明粘细菌是新型次生代谢产物的丰富来源，其中许多化合物具有有趣且有时独特的作用机制。已经阐明了大约50种基本结构和近300种结构变体，并且几乎所有这些都被证明是新化合物。几种粘细菌物质可能有很好的应用机会。
