Frias Juan C, Williams Kevin Jon, Fisher Edward A, Fayad Zahi A
Imaging Science Laboratories, Department of Radiology, Zena and Michael A. Wiener Cardiovascular Institute, Mount Sinai School of Medicine, New York, New York, USA.
J Am Chem Soc. 2004 Dec 22;126(50):16316-7. doi: 10.1021/ja044911a.
A new contrast agent for MRI based on recombinant HDL-like nanoparticles has been prepared. It shows a great potential as a contrast agent for atherosclerotic plaques in a relative short time (24 h post-injection) as it is selective for the plaques and is an endogenous molecule. It also can distinguish between different types of plaques as the enhancement obtained is different, depending on plaque composition.
一种基于重组高密度脂蛋白样纳米颗粒的新型磁共振成像造影剂已被制备出来。它在相对较短的时间内（注射后24小时）显示出作为动脉粥样硬化斑块造影剂的巨大潜力，因为它对斑块具有选择性且是一种内源性分子。它还可以区分不同类型的斑块，因为根据斑块成分的不同，获得的增强效果也不同。
