Amirnovin Ramin, Williams Ziv M, Cosgrove G Rees, Eskandar Emad N
Department of Neurosurgery, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114-3117, USA.
J Neurosci. 2004 Dec 15;24(50):11302-6. doi: 10.1523/JNEUROSCI.3242-04.2004.
There is considerable evidence that abnormal oscillatory activity in the basal ganglia contributes to the pathogenesis of Parkinson's disease. However, little is known regarding the relationship of oscillations to volitional movements. Our goal was to evaluate the dynamics of oscillatory activity at rest and during movement. We performed microelectrode recordings from the subthalamic nucleus (STN) of patients undergoing deep brain stimulation surgery. During recordings, the patients used a joystick to guide a cursor to one of four targets on a monitor. We recorded 184 cells and 47 pairs of cells in 11 patients. At rest, 26 cells (14%) demonstrated significant oscillatory activity, with a mean frequency of 18 Hz. During movement, this oscillatory activity was either reduced or completely abolished in all of the cells. At rest, 18 pairs (38%) of cells in five patients exhibited synchronized oscillatory activity, with a mean frequency of 15 Hz. In 17 of the 18 pairs, both of the cells exhibited oscillations, and, in one pair, only one of the cells was oscillatory. These synchronized oscillations were also significantly decreased with movement. There was a strong inverse correlation between firing rates and oscillatory activity. As the firing rates increased with movement, there was a decrease in oscillatory activity. These findings suggest that visually guided movements are associated with a dampening and desynchronization of oscillatory activity in STN neurons. One possible explanation for these observations is that the increased cortical drive associated with movement preparation and execution leads to a transient dampening of STN oscillations, hence facilitating movement.
有大量证据表明，基底神经节的异常振荡活动与帕金森病的发病机制有关。然而，关于振荡与随意运动之间的关系，我们知之甚少。我们的目标是评估静息和运动期间振荡活动的动态变化。我们对接受深部脑刺激手术患者的丘脑底核（STN）进行了微电极记录。记录过程中，患者使用操纵杆将光标引导至监视器上的四个目标之一。我们记录了11例患者的184个细胞和47对细胞。静息时，26个细胞（14%）表现出显著的振荡活动，平均频率为18赫兹。运动期间，所有细胞的这种振荡活动要么减弱，要么完全消失。静息时，5例患者中的18对（38%）细胞表现出同步振荡活动，平均频率为15赫兹。在这18对细胞中的17对中，两个细胞均表现出振荡，而在一对细胞中，只有一个细胞振荡。这些同步振荡在运动时也显著减少。放电率与振荡活动之间存在很强的负相关。随着运动时放电率增加，振荡活动减少。这些发现表明，视觉引导的运动与STN神经元振荡活动的抑制和去同步化有关。对这些观察结果的一种可能解释是，与运动准备和执行相关的皮质驱动增加导致STN振荡的短暂抑制，从而促进运动。
