Yan Weili, Chen Shufeng, Huang Jianfeng, Shen Yan, Qiang Boqin, Gu Dongfeng
Division of Population Genetics and Prevention, Cardiovascular Institute and Fu Wai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100037, China.
Obes Res. 2004 Nov;12(11):1733-7. doi: 10.1038/oby.2004.214.
The current study investigated the association between PLIN polymorphisms and the combination of hypertension and obesity (HO) and the related clinical features. The polymorphisms 1237 (T/C), 1243 (C/T), and 1323 (C/G) were genotyped in 503 cases with HO and 511 unrelated controls. No associations between polymorphism 1237 (T/C) or 1243 (C/T) and HO were found. However, total cholesterol (TC) levels were significantly different among genotypes of polymorphism 1243 (p = 0.023, power = 0.55). In male cases, 1243T carriers (TT + CT) had higher TC, high-density lipoprotein-cholesterol, and low-density lipoprotein-cholesterol levels compared with CC homozygote carriers (5.23 +/- 0.88 vs. 4.98 +/- 0.90, p = 0.024; 1.13 +/- 0.23 vs. 1.07 +/- 0.22 mM, p = 0.034; 3.3 +/- 0.78 vs. 3.11 +/- 0.80, p = 0.03, respectively). Additionally, 1243T allele carriers were more prevalent among the subjects with both HO and elevated TC levels (> or =5.2 mM) than those with HO and optimal TC levels (<5.2 mM) (chi(2) = 8.53; p < 0.003; odds ratio, 1.69; 95% confidence interval, 1.19 approximately 2.42). Multiple logistic regression analysis suggested a significant contribution of polymorphism 1243 to the elevated TC levels after controlling for conventional risk factors (odds ratio, 1.48; 95% confidence interval, 1.14 approximately 1.91; p = 0.003). Polymorphism 1243 in the PLIN gene did not seem to be associated with HO but with TC levels in Chinese. The PLIN gene may be involved in human lipid metabolism.
本研究调查了PLIN基因多态性与高血压合并肥胖症（HO）及其相关临床特征之间的关联。对503例HO患者和511名无亲缘关系的对照者进行了1237（T/C）、1243（C/T）和1323（C/G）多态性的基因分型。未发现1237（T/C）或1243（C/T）多态性与HO之间存在关联。然而，1243多态性各基因型之间的总胆固醇（TC）水平存在显著差异（p = 0.023，检验效能 = 0.55）。在男性患者中，与CC纯合子携带者相比，1243T携带者（TT + CT）的TC、高密度脂蛋白胆固醇和低密度脂蛋白胆固醇水平更高（分别为5.23±0.88 vs. 4.98±0.90，p = 0.024；1.13±0.23 vs. 1.07±0.22 mM，p = 0.034；3.3±0.78 vs. 3.11±0.80，p = 0.03）。此外，与HO且TC水平正常（<5.2 mM）的受试者相比，HO且TC水平升高（≥5.2 mM）的受试者中1243T等位基因携带者更为普遍（χ2 = 8.53；p < 0.003；比值比，1.69；95%置信区间，1.19至2.42）。多因素logistic回归分析表明，在控制传统危险因素后，1243多态性对TC水平升高有显著影响（比值比，1.48；95%置信区间，1.14至1.91；p = 0.003）。在中国人群中，PLIN基因的1243多态性似乎与HO无关，但与TC水平有关。PLIN基因可能参与人体脂质代谢。
