Department of epidemiology and biostatistics, Institute of Basic Medical Science, Chinese Academy of Medical Sciences and School of Basic Medicine, Peking Union Medical College, Beijing, China.
BMJ Open. 2013 Mar 15;3(3):e002279. doi: 10.1136/bmjopen-2012-002279.
To explore the sociodemographic patterning of risk factors for cardiovascular disease (CVD) in three isolated-based subgroups of the Uyghur population in Xinjiang, China.
A cross-sectional study. Between 2005 and 2008, a non-probability sampling design method was used to select three specific groups of the Uyghur rural populations based on their potential socioeconomic status (ie, isolated, semi-isolated and open-environment status).
Three communities (named Desert, Turpan and Yuli Rob) in Southern Xinjiang autonomous region, China.
1656 people were included in this study. The inclusion criteria were that all participants were 18 years or older, they were descendants of at least three generations living in the same region, and there was no history of intermarriage.
The prevalence of CVD risk factors (ie, tobacco use, alcohol use, obesity, dyslipidemia, hypertension, diabetes, etc) was assessed.
Compared with the Desert and Turpan communities, Yuli Rob had the highest levels of obesity, dyslipidemia and hypertension, and the Desert had the lowest levels of CVD risk factors. Age standardisation slightly altered the estimates, though the patterns remained unchanged. Some unique characteristics were also found. For example, the Desert group displayed significantly lower high-density lipoprotein cholesterol (HDLC) level compared with Yuli Rob and Turpan groups. The mean values were 0.63, 1.06 and 1.45 mmol/l for men and 0.64, 1.22 and 1.51 mmol/l for women (p<0.0001). The HDLC levels in the Desert group increased with increase in body mass index and fasting glucose levels, which was inconsistent with previous studies.
Identifying the unique CVD risk factors of the ethnic-specific populations is very important in development of tailored strategies for the prevention of CVD.
探讨中国新疆维吾尔族人群中基于 3 个隔离聚居社区的心血管疾病（CVD）危险因素的社会人口学分布模式。
横断面研究。2005 年至 2008 年期间，采用非概率抽样设计方法，根据潜在社会经济地位，选择了维吾尔族农村人群的 3 个特定亚组（即隔离、半隔离和开放环境状态）。
中国南疆地区的三个社区（分别命名为沙漠、吐鲁番和于田罗布）。
本研究共纳入 1656 人。纳入标准为年龄均≥18 岁，为至少三代同堂居住在同一地区的后裔，且无通婚史。
评估 CVD 危险因素（即吸烟、饮酒、肥胖、血脂异常、高血压、糖尿病等）的流行情况。
与沙漠和吐鲁番社区相比，于田罗布的肥胖、血脂异常和高血压发生率最高，沙漠社区的 CVD 危险因素发生率最低。年龄标准化略微改变了估计值，但模式保持不变。还发现了一些独特的特征。例如，与于田罗布和吐鲁番社区相比，沙漠社区的男性和女性高密度脂蛋白胆固醇（HDLC）水平明显较低，分别为 0.63、1.06 和 1.45mmol/L，0.64、1.22 和 1.51mmol/L（p<0.0001）。随着体质指数和空腹血糖水平的升高，沙漠组的 HDLC 水平增加，这与之前的研究结果不一致。
确定特定民族人群特有的 CVD 危险因素对于制定针对 CVD 预防的个体化策略非常重要。
