Department of Epidemiology, College of Public Health, Zhengzhou University, Zhengzhou 450001, Henan, China.
Biomed Environ Sci. 2009 Oct;22(5):442-7. doi: 10.1016/S0895-3988(10)60023-2.
To identify the association between PLIN 1237 polymorphism and obesity in Chinese Han adults.
A total of 994 adults (157 obese subjects, 322 overweight subjects, and 515 normal controls) were recruited from two rural communities. PLIN 1237 polymorphism was genotyped by polymerase chain reaction-restriction-fragment-length-polymorphism (PCR-RFLP). Association between PLIN polymorphisms and obesity status was estimated by ordinal logistic regression.
The three genotypes of PLIN 1237 were detected with a percentage of 54.3%, 37.1%, and 8.6% in TT, TC, and CC genotypes, respectively. For the PLIN 1237 polymorphism locus, the frequency of alleles T and C was 0.73 and 0.27, respectively. The PLIN 1237 polymorphisms were in Hardy-Weinberg equilibrium. PLIN 1237 polymorphism was not associated with obesity. The odds ratio for overweight or obesity for the CC+TC genotype was 0.8 (0.4, 1.4) in women (P = 0.4) and 0.6 (0.3, 1.3) in men (P = 0.2) after adjustment for age, education, household income and alcohol consumption, smoking, and physical activity.
Chinese Han adults have a lower frequency of variant-allele C in PLIN 1237. PLIN 1237 T > C polymorphism is not significantly associated with obesity in northern Chinese adults.
鉴定 PLIN1237 多态性与中国汉族成年人肥胖的关联性。
从两个农村社区招募了 994 名成年人（157 名肥胖者、322 名超重者和 515 名正常对照者）。通过聚合酶链反应-限制性片段长度多态性（PCR-RFLP）对 PLIN1237 多态性进行基因分型。通过有序逻辑回归估计 PLIN 多态性与肥胖状态之间的关联。
检测到 PLIN1237 的三种基因型，其 TT、TC 和 CC 基因型的百分比分别为 54.3%、37.1%和 8.6%。对于 PLIN1237 多态性位点，等位基因 T 和 C 的频率分别为 0.73 和 0.27。PLIN1237 多态性处于哈迪-温伯格平衡状态。PLIN1237 多态性与肥胖无关。CC+TC 基因型的超重或肥胖的比值比在女性中为 0.8（0.4，1.4）（P=0.4），在男性中为 0.6（0.3，1.3）（P=0.2），经年龄、教育、家庭收入和饮酒、吸烟和体力活动调整后。
中国汉族成年人 PLIN1237 中的变异等位基因 C 的频率较低。PLIN1237 T>C 多态性与中国北方成年人的肥胖无显著相关性。
