硅酸钙镁（硅钙石）生物活性陶瓷的制备与特性
Preparation and characteristics of a calcium magnesium silicate (bredigite) bioactive ceramic.
作者信息
Wu Chengtie, Chang Jiang, Wang Junying, Ni Siyu, Zhai Wanyin
机构信息
Biomaterials and Tissue Engineering Research Center, Shanghai Institute of Ceramics, Chinese Academy of Sciences, 1295 Dingxi Road, Shanghai 200050, People's Republic of China.
出版信息
Biomaterials. 2005 Jun;26(16):2925-31. doi: 10.1016/j.biomaterials.2004.09.019.
In this study, new bredigite (Ca7MgSi4O16) ceramics were prepared by sintering sol-gel-derived bredigite powder compacts at 1350 degrees C for 8 h. The bending strength, fracture toughness and Young's modulus were about 156 MPa, 1.57 MPa m(1/2) and 43 GPa, respectively. The in vitro bioactivity of the bredigite ceramics was evaluated by investigating the apatite-formation ability in simulated body fluid (SBF) and the effect of ionic products from bredigite dissolution on the mouse fibroblasts cell line L929. In addition, the in vitro biocompatibility of the bredigite ceramics was evaluated by osteoblasts adhesion and proliferation assay. The results showed that bredigite ceramics could induce HAp formation in SBF. The products from bredigite dissolution significantly promoted cell growth at a certain concentration range. Furthermore, osteoblasts adhered and spread well on bredigite ceramics, and osteoblasts proliferation on bredigite ceramics was obvious.
在本研究中，通过将溶胶-凝胶法制备的钙镁硅石（Ca7MgSi4O16）粉末压块在1350℃下烧结8小时来制备新型钙镁硅石陶瓷。其弯曲强度、断裂韧性和杨氏模量分别约为156MPa、1.57MPa·m(1/2)和43GPa。通过研究在模拟体液（SBF）中的磷灰石形成能力以及钙镁硅石溶解产生的离子产物对小鼠成纤维细胞系L929的影响，来评估钙镁硅石陶瓷的体外生物活性。此外，通过成骨细胞黏附与增殖试验评估钙镁硅石陶瓷的体外生物相容性。结果表明，钙镁硅石陶瓷可在SBF中诱导羟基磷灰石（HAp）形成。在一定浓度范围内，钙镁硅石溶解产生的产物显著促进细胞生长。此外，成骨细胞在钙镁硅石陶瓷上黏附良好且铺展充分，在钙镁硅石陶瓷上成骨细胞的增殖明显。
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