Brunello Giulia, Elsayed Hamada, Biasetto Lisa
Department of Management and Engineering, University of Padova, Stradella San Nicola 3, 36100 Vicenza, Italy.
Department of Neurosciences, Section of Dentistry, University of Padova, Via Giustiniani 2, 35128 Padova, Italy.
Materials (Basel). 2019 Sep 10;12(18):2929. doi: 10.3390/ma12182929.
The overall success and long-term life of the medical implants are decisively based on the convenient osseointegration at the hosting tissue-implant interface. Therefore, various surface modifications and different coating approaches have been utilized to the implants to enhance the bone formation and speed up the interaction with the surrounding hosting tissues, thereby enabling the successful fixation of implants. In this review, we will briefly present the main metallic implants and discuss their biocompatibility and osseointegration ability depending on their chemical and mechanical properties. In addition, as the main goal of this review, we explore the main properties of bioactive glasses and silica-based ceramics that are used as coating materials for both orthopedic and dental implants. The current review provides an overview of these bioactive coatings, with a particular emphasis on deposition methods, coating adhesion to the substrates and apatite formation ability tested by immersion in Simulated Body Fluid (SBF). and performances in terms of biocompatibility, biodegradability and improved osseointegration are examined as well.
医用植入物的整体成功和长期使用寿命在很大程度上取决于其在宿主组织与植入物界面处的便捷骨整合。因此,人们对植入物采用了各种表面改性和不同的涂层方法,以增强骨形成并加快与周围宿主组织的相互作用,从而实现植入物的成功固定。在本综述中,我们将简要介绍主要的金属植入物,并根据其化学和机械性能讨论它们的生物相容性和骨整合能力。此外,作为本综述的主要目标,我们探讨用作骨科和牙科植入物涂层材料的生物活性玻璃和二氧化硅基陶瓷的主要性能。本综述概述了这些生物活性涂层,特别强调了沉积方法、涂层与基材的附着力以及通过浸泡在模拟体液(SBF)中测试的磷灰石形成能力。同时还研究了它们在生物相容性、生物降解性和改善骨整合方面的性能。