酿酒酵母细胞类型指定回路的基因组剖析。
Genomic dissection of the cell-type-specification circuit in Saccharomyces cerevisiae.
作者信息
Galgoczy David J, Cassidy-Stone Ann, Llinás Manuel, O'Rourke Sean M, Herskowitz Ira, DeRisi Joseph L, Johnson Alexander D
机构信息
Department of Biochemistry and Biophysics, University of California, 600 16th Street, San Francisco, CA 94143-2200, USA.
出版信息
Proc Natl Acad Sci U S A. 2004 Dec 28;101(52):18069-74. doi: 10.1073/pnas.0407611102. Epub 2004 Dec 16.
Abstract
The budding yeast Saccharomyces cerevisiae has three cell types (a cells, alpha cells, and a/alpha cells), each of which is specified by a unique combination of transcriptional regulators. This transcriptional circuit has served as an important model for understanding basic features of the combinatorial control of transcription and the specification of cell type. Here, using genome-wide chromatin immunoprecipitation, transcriptional profiling, and phylogenetic comparisons, we describe the complete cell-type-specification circuit for S. cerevisiae. We believe this work represents a complete description of cell-type specification in a eukaryote.
摘要
出芽酵母酿酒酵母有三种细胞类型（a细胞、α细胞和a/α细胞），每种细胞类型都由转录调节因子的独特组合所决定。这个转录调控回路已成为理解转录组合控制的基本特征和细胞类型决定的重要模型。在这里，我们通过全基因组染色质免疫沉淀、转录谱分析和系统发育比较，描述了酿酒酵母完整的细胞类型决定回路。我们认为这项工作代表了对真核生物细胞类型决定的完整描述。
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