Harukuni I, Ishizawa Y, Nishikawa T, Takeshima R, Dohi S, Naito H
Department of Anesthesiology, Tsukuba University Hospital.
Masui. 1992 Mar;41(3):455-9.
We experienced a case in which a 66 year-old male patient developed anaphylactic shock followed by ventricular fibrillation, possibly due to intravenous aspiration of chlorhexidine used for topical application when right internal jugular vein was punctured. He was successfully resuscitated without any sequelae. Although lymphocyte transformation test failed to identify the specific allergen, IgE antibodies against chlorhexidine in the patient's serum were detected by radioallergosorbent technique. Chlorhexidine is an extensively used antiseptic, but there have been many reports regarding severe adverse reactions associated with its use. Chlorhexidine does not seem to be a safe antiseptic.
我们遇到过这样一个病例，一名66岁男性患者出现过敏性休克，随后发生心室颤动，可能是由于在穿刺右颈内静脉时静脉误吸了用于局部应用的氯己定。他成功复苏，没有留下任何后遗症。尽管淋巴细胞转化试验未能识别出特定过敏原，但通过放射变应原吸附技术检测到患者血清中存在抗氯己定的IgE抗体。氯己定是一种广泛使用的防腐剂，但有许多关于其使用相关严重不良反应的报道。氯己定似乎不是一种安全的防腐剂。
