Fujita S, Sumita S, Kawana S, Iwasaki H, Namiki A
Department of Anesthesiology, Sapporo Medical University School of Medicine.
Masui. 1997 Aug;46(8):1118-21.
We reported two patients who developed skin eruptions and severe hypotension immediately after scrubbing their wound in the leg using 4% chlorhexidine solution. Both patients were successfully treated by epinephrine administration. Patient-1 (a 42-year-old man) had his wound scrubbed using this antiseptic several times before the operation. He showed a positive skin scratch test for chlorhexidine. Patient-2 (a 74-year-old man) had no prior treatment with chlorhexidine. Positive lymphocyte transformation test was not demonstrated in these patients. It has been reported that more than 10% of patients with anaphylactic shock induced by chlorhexidine use had previous exposure to it and 80% of them had it used for mucosa or wound washing. From these results, we should keep it in mind that chlorhexidine is not likely to be a safe antiseptic and can possibly induce anaphylactic shock.
我们报告了两名患者，他们在使用4%洗必泰溶液擦洗腿部伤口后立即出现皮肤疹和严重低血压。两名患者均通过给予肾上腺素成功治疗。患者1（一名42岁男性）在手术前曾多次使用这种消毒剂擦洗伤口。他对洗必泰的皮肤划痕试验呈阳性。患者2（一名74岁男性）之前未用过洗必泰治疗。这些患者未显示淋巴细胞转化试验阳性。据报道，因使用洗必泰引起过敏性休克的患者中，超过10%曾接触过洗必泰，其中80%曾将其用于黏膜或伤口冲洗。从这些结果来看，我们应该记住，洗必泰不太可能是一种安全的消毒剂，并且可能诱发过敏性休克。
