Toomey Matthew
West End Anesthesia Group, Richmond, VA, USA.
AANA J. 2013 Jun;81(3):209-14.
Chlorhexidine is a synthetic antiseptic and disinfectant that has been widely used in the healthcare setting and in everyday household products. In addition to oral rinses and skin preparations, manufacturers have incorporated chlorhexidine coatings into medical devices such as urinary catheters, endotracheal tubes, and central venous catheters in an effort to reduce infection rates. Despite the ubiquitous use of chlorhexidine, severe reactions, such as anaphylaxis, are relatively rare. This case report describes a 65-year-old patient scheduled for coronary artery bypass graft surgery who preoperatively experienced anaphylaxis to chlorhexidine delivered through multiple routes of administration. To our knowledge, this is the first reported perioperative anaphylactic reaction to chlorhexidine in the United States. A review of the anaphylaxis cascade, the prevalence of hospital-acquired infections, and the risks of using chlorhexidine are thoroughly discussed. It must be appreciated that life-threatening reactions to this commonly used agent are more than just a theoretical possibility.
洗必泰是一种合成抗菌剂和消毒剂，已广泛应用于医疗保健环境以及日常家用产品中。除了口腔含漱液和皮肤制剂外，制造商还将洗必泰涂层应用于尿管、气管内导管和中心静脉导管等医疗器械中，以降低感染率。尽管洗必泰被广泛使用，但严重反应，如过敏反应，相对较少见。本病例报告描述了一名计划进行冠状动脉搭桥手术的65岁患者，术前通过多种给药途径对洗必泰发生过敏反应。据我们所知，这是美国首次报道的围手术期对洗必泰的过敏反应。本文还对过敏反应级联、医院获得性感染的患病率以及使用洗必泰的风险进行了全面讨论。必须认识到，对这种常用药物的危及生命的反应不仅仅是一种理论上的可能性。
