通过TEMPO/铜接力催化在连续流中实现电催化C(sp)-H/C(sp)-H交叉偶联。
Electrocatalytic C(sp)-H/C(sp)-H cross-coupling in continuous flow through TEMPO/copper relay catalysis.
作者信息
Guo Bin, Xu Hai-Chao
机构信息
Key Laboratory of Chemical Biology of Fujian Province and College of Chemistry and Chemical Engineering, Xiamen University, People's Republic of China.
出版信息
Beilstein J Org Chem. 2021 Oct 28;17:2650-2656. doi: 10.3762/bjoc.17.178. eCollection 2021.
Electrocatalytic dehydrogenative C(sp)-H/C(sp)-H cross-coupling of tetrahydroisoquinolines with terminal alkynes has been achieved in a continuous-flow microreactor through 2,2,6,6-tetramethylpiperidine 1-oxyl (TEMPO)/copper relay catalysis. The reaction is easily scalable and requires low concentration of supporting electrolyte and no external chemical oxidants or ligands, providing straightforward and sustainable access to 2-functionalized tetrahydroisoquinolines.
通过2,2,6,6-四甲基哌啶1-氧基（TEMPO）/铜接力催化，在连续流动微反应器中实现了四氢异喹啉与末端炔烃的电催化脱氢C(sp)-H/C(sp)-H交叉偶联。该反应易于放大，所需支持电解质浓度低，无需外部化学氧化剂或配体，为制备2-官能化四氢异喹啉提供了直接且可持续的方法。
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