Feller Marla B
Department of Molecular and Cell Biology, University of California, Berkeley, California 94720, USA.
Neural Dev. 2009 Jul 6;4:24. doi: 10.1186/1749-8104-4-24.
Prior to eye-opening and the development of visual responses, the retina exhibits highly correlated spontaneous firing pattens termed retinal waves. Disruption of the normal spontaneous firing pattern either genetically or pharmacologically prevents the eye-specific refinement of retinogeniculate afferents. Here I provide the evidence that retinal waves play an instructive role in this process. In addition, I argue that a full understanding requires an identification of the features of retinal activity that drive the refinement as well as an understanding of mechanisms that transform these signals into axonal rearrangements.
在睁眼和视觉反应发展之前，视网膜呈现出高度相关的自发放电模式，称为视网膜波。通过基因或药理学手段破坏正常的自发放电模式会阻止视网膜-膝状体传入纤维的眼特异性精细化。在此，我提供证据表明视网膜波在这一过程中起指导作用。此外，我认为要全面理解这一过程，需要确定驱动精细化的视网膜活动特征，以及理解将这些信号转化为轴突重排的机制。
