Money E A, Kirk R C, McNaughton N
Department of Psychology, University of Otago, Dunedin, New Zealand.
Neuropsychologia. 1992 Feb;30(2):133-43. doi: 10.1016/0028-3932(92)90023-f.
Patients diagnosed with senile dementia of the Alzheimer type (SDAT) were compared with control subjects on a computerized delayed matching to sample task. Performance was assessed with a measure of discriminability at zero delay and a measure of rate of forgetting--these are the two parameters of an exponential function derived from extensive animal testing. The SDAT group showed significantly poorer discriminability at zero delay than controls but equivalent rates of forgetting over a 32-sec delay. These data suggest that SDAT may have little effect on the decay rate of the short term (or 'primary') memory trace and may instead affect encoding, initial storage or retrieval mechanisms. The effects of SDAT on this task are consistent with previous results with anticholinergic agents in rats.
将被诊断为阿尔茨海默型老年痴呆症（SDAT）的患者与对照组受试者进行了一项计算机化延迟匹配样本任务的比较。通过零延迟时的辨别力测量和遗忘率测量来评估表现——这是从大量动物实验得出的指数函数的两个参数。SDAT组在零延迟时的辨别力明显比对照组差，但在32秒延迟期间的遗忘率相当。这些数据表明，SDAT可能对短期（或“初级”）记忆痕迹的衰减率影响不大，而是可能影响编码、初始存储或检索机制。SDAT对这项任务的影响与之前在大鼠中使用抗胆碱能药物的结果一致。
