Selco Scott L, Liebeskind David S
UCLA Stroke Center and Department of Neurology, 710 Westwood Plaza, Los Angeles, CA 90095, USA.
Curr Cardiol Rep. 2005 Jan;7(1):10-5. doi: 10.1007/s11886-005-0004-8.
Ischemic stroke remains a significant cause of morbidity and mortality. Current therapeutic options for acute ischemic stroke include intravenous thrombolysis and endovascular approaches for recanalization of proximal arterial occlusion. The rapid identification of underlying stroke etiology or mechanism may facilitate selection criteria for emergent therapy. Hyperacute imaging plays an integral role in the delineation of stroke pathophysiology and the formulation of rational stroke therapy. Hyperacute imaging of ischemic stroke may demonstrate proximal vascular occlusion, compensatory collateral circulation, residual or collateral tissue perfusion, and the differentiation of ischemic core from penumbral regions. Characterization of the ischemic field, including core and penumbra, with various mismatch models on multimodal computed tomography or MRI may refine current therapeutic strategies for cerebral ischemia. The diagnostic and therapeutic role of hyperacute imaging has emerged as a pivotal component in the evaluation and management of ischemic stroke.
缺血性中风仍然是发病和死亡的重要原因。目前急性缺血性中风的治疗选择包括静脉溶栓和近端动脉闭塞再通的血管内治疗方法。快速识别潜在的中风病因或机制可能有助于制定紧急治疗的选择标准。超急性期成像在描绘中风病理生理学和制定合理的中风治疗方案中起着不可或缺的作用。缺血性中风的超急性期成像可能显示近端血管闭塞、代偿性侧支循环、残余或侧支组织灌注，以及缺血核心与半暗带区域的区分。利用多模态计算机断层扫描或磁共振成像上的各种不匹配模型对包括核心和半暗带在内的缺血区域进行特征描述，可能会完善目前针对脑缺血的治疗策略。超急性期成像的诊断和治疗作用已成为缺血性中风评估和管理的关键组成部分。
